Evidence map›Paper›PMID 30504771›Full record

ArticleNature communications2018

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.

Shu-Chen Liu, Tien Hsu, Yu-Sun Chang, An-Ko Chung, Shih Sheng Jiang, Chun-Nan OuYang, Chiou-Hwa Yuh, Chuen Hsueh, Ya-Ping Liu, Ngan-Ming Tsang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

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  13. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
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  17. Chrysin serves as a novel inhibitor of DGKActa pharmaceutica Sinica. B · 2021
    Article
  18. Review
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  20. [Overexpression of leukemia inhibitory factor enhances chemotherapy tolerance of endometrial cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shu-Chen LiuDepartment of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist., 32001, Taoyuan City, Taiwan. jennyliu66@gmail.com.
Tien HsuDepartment of Biomedical Sciences and Engineering, National Central University, 300, Zhongda Rd., Jhongli Dist., 32001, Taoyuan City, Taiwan.
Yu-Sun ChangMolecular Medicine Research Center, Chang Gung University, 259, Wenhua 1st Rd., Guishan Dist., 33302, Taoyuan City, Taiwan.
An-Ko ChungGraduate Institute of Biomedical Sciences, Chang Gung University, 259, Wenhua 1st Rd., Guishan Dist., 33302, Taoyuan City, Taiwan.
Shih Sheng JiangNational Institute of Cancer Research, National Health Research Institutes, 35 Keyan Rd., Zhunan, 35053, Miaoli County, Taiwan.ORCID http://orcid.org/0000-0003-1909-437X
Chun-Nan OuYangMolecular Medicine Research Center, Chang Gung University, 259, Wenhua 1st Rd., Guishan Dist., 33302, Taoyuan City, Taiwan.
Chiou-Hwa YuhInstitute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Rd., Zhunan, 35053, Miaoli County, Taiwan.ORCID http://orcid.org/0000-0002-2356-1551
Chuen HsuehDepartment of Pathology, Chang Gung Memorial Hospital at Lin-Kou, 5 Fuxing St., Guishan Dist., 333, Taoyuan City, Taiwan.
Ya-Ping LiuPathology Core of the Molecular Medicine Research Center, Chang Gung University, 5, Fuxing St., Guishan Dist., 333, Taoyuan City, Taiwan.
Ngan-Ming TsangDepartment of Radiation Oncology, Chang Gung Memorial Hospital and University at Lin-Kou, 5, Fuxing St., Guishan Dist., 333, Taoyuan City, Taiwan. tsangrt123@gmail.com.
Chang Gung University · TWChang Gung Memorial Hospital · TWNational Central University · TWNational Health Research Institutes · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis remains a clinically unsolved issue in nasopharyngeal carcinoma. Here, we report that higher levels of cytoplasmic leukemia inhibitory factor (LIF) and LIF receptor are correlated with poorer metastasis/recurrence-free survival. Further, single nucleotide variations and signal peptide mutation of LIF are identified in NPC. Cytoplasmic LIF reprograms the invasive mode from collective to mesenchymal migration via acquisition of EMT and invadopodia-associated characteristics. Higher cytoplasmic LIF enhances cancer vascular dissemination and local invasion mechanistically through modulation of YAP1-FAK/PXN signaling. Immunohistochemical analyses of NPC biopsies reveal a positive correlation of cytoplasmic LIF expression with focal adhesion kinases. Pharmaceutical intervention with AZD0530 markedly reverses LIF-mediated cancer dissemination and local invasion through promotion of cytoplasmic accumulation of YAP1 and suppression of focal adhesion kinases. Given the significant role of LIF/YAP1-focal adhesion signaling in cancer dissemination, targeting of this pathway presents a promising opportunity to block metastasis.

Indexed as

Adaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAnimalsBlotting, WesternEpithelial-Mesenchymal TransitionFemaleFocal Adhesion Kinase 1HumansHuman Umbilical Vein Endothelial CellsImmunohistochemistryLeukemia Inhibitory FactorMaleMiceMice, SCIDAdaptor Proteins, Signal TransducingFocal Adhesion Kinase 1Leukemia Inhibitory FactorPaxillinPhosphoproteinsPTK2 protein, humanPXN protein, humanReceptors, OSM-LIFTranscription FactorsYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID30504771
PMCPMC6269507
OpenAlexW2902551661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.