ArticleNature communications2018
Subcellular connectomic analyses of energy networks in striated muscle.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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Who cites it
92 citing papers in PubMed.
- Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes.Nature communications · 2026Trial
- Effects of exercise in a fed or fasted state on mitochondrial dynamics regulators in the skeletal muscle of recreationally active males.Experimental physiology · 2026Trial
- Trial
- Mitochondrial cristae density is increased following high-intensity interval training in men with type 2 diabetes.Diabetologia · 2026Article
- Physiological levels of 3-hydroxykynurenine alter mitochondrial function and morphology in neuronal cells.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial Activity Localization in the Skeletal Muscle and Its Individual Fibers Across Tetrapods.Biology of the cell · 2026Article
- Mitochondrial Network Dynamics in Aging: Cellular Mechanisms, Intercellular Communication, and Their Impact on Tissue Adaptability.International journal of molecular sciences · 2026Review
- Cardiac myofibril networks induce shear stress.NPJ systems biology and applications · 2026Article
- Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Region-specific human cardiac extracellular vesicles differentially regulate mitochondrial function.Extracellular vesicles and circulating nucleic acids · 2026Article
- A semantic segmentation model to predict subcellular glycogen localization using transmission electron microscopy images.PloS one · 2026Article
- Morphological alterations of peridroplet mitochondria in human liver biopsy.Scientific reports · 2025Article
- Retrospective transcriptomic analysis indicates temporal dysregulation of mitochondrial genes and metabolic pathways after volumetric muscle loss injury.Physiological reports · 2025Article
- Physiological Muscle Function Is Controlled by the Skeletal Endocannabinoid System in Murine Skeletal Muscles.International journal of molecular sciences · 2025Article
- Efficient cell-wide mapping of mitochondria in electron microscopic volumes using webKnossos.Cell reports methods · 2025Article
- Amyloid-induced mitochondrial network disruption in neurons monitored by STED super-resolution imaging.Frontiers in cell and developmental biology · 2025Article
- Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle.Frontiers in physiology · 2025Article
- Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism.Kidney international reports · 2024Review
- An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease.The EMBO journal · 2024Article
- Mitochondrial membrane lipids in the regulation of bioenergetic flux.Cell metabolism · 2024Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Mapping biological circuit connectivity has revolutionized our understanding of structure-function relationships. Although connectomic analyses have primarily focused on neural systems, electrical connectivity within muscle mitochondrial networks was recently demonstrated to provide a rapid mechanism for cellular energy distribution. However, tools to evaluate organelle connectivity with high spatial fidelity within single cells are currently lacking. Here, we developed a framework to quantitatively assess mitochondrial network connectivity and interactions with cellular sites of energy storage, utilization, and calcium cycling in cardiac, oxidative, and glycolytic muscle. We demonstrate that mitochondrial network configuration, individual mitochondrial size and shape, and the junctions connecting mitochondria within each network are consistent with the differing contraction demands of each muscle type. Moreover, mitochondria-lipid droplet interaction analyses suggest that individual mitochondria within networks may play specialized roles regarding energy distribution and calcium cycling within the cell and reveal the power of connectomic analyses of organelle interactions within single cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.