Evidence map›Paper›PMID 30504506›Full record

ArticleThe Journal of rheumatology2019

Characteristics of Accelerated Hand Osteoarthritis: Data from the Osteoarthritis Initiative.

Julie E Davis, Lena F Schaefer, Timothy E McAlindon, Charles B Eaton, Mary B Roberts, Ida K Haugen, Stacy E Smith, Jeffrey Duryea, Bing Lu, Jeffrey B Driban

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Julie E DavisFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.ORCID 0000-0002-1327-484X
Lena F SchaeferFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Timothy E McAlindonFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Charles B EatonFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Mary B RobertsFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Ida K HaugenFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Stacy E SmithFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Jeffrey DuryeaFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Bing LuFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Jeffrey B DribanFrom the Division of Rheumatology, Tufts Medical Center; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, Rhode Island, USA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. jeffrey.driban@tufts.edu.ORCID 0000-0001-6098-4273
Brigham and Women's Hospital · US

Funding

Constitutional and metabolic factors associated with the development of Hand OAR01AR066378 · NIAMS · TUFTS MEDICAL CENTER · PI MCALINDON, TIMOTHY E · 2015 to 2018
$2.6M
Metabolites of Dietary Intake and Risk of Knee OsteoarthritisR01AR074447 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LU, BING · 2019 to 2022
$2.6M
Characterization of Rapidly Progressive Knee OsteoarthritisR01AR065977 · NIAMS · TUFTS MEDICAL CENTER · PI DRIBAN, JEFFREY B · 2015 to 2018
$1.5M
NIAMS NIH HHS R01 AR065977NIAMS NIH HHS R01 AR066378NIAMS NIH HHS R01 AR074447
6 · The paper itself

Abstract

objectiveWe aimed to determine whether hand joints develop an accelerated form of osteoarthritis (OA) and to characterize individuals who develop accelerated hand osteoarthritis (AHOA).

methodsWe evaluated 3519 participants in the Osteoarthritis Initiative with complete data for baseline and 48-month radiographic hand osteoarthritis (HOA). One reader scored posteroanterior radiographs of the dominant hand using a modified Kellgren-Lawrence (KL) scale and another reader scored the presence of central or marginal erosions. A third reader read images flagged for signs of diseases other than OA. We defined AHOA as ≥ 1 joints that progressed from a KL grade of 0 or 1 at baseline to KL grade 3 or 4 at 48 months.

resultsThe definition of AHOA was met by 1% over 4 years: 37 hands had 1 joint affected and 1 hand had 2 joints affected. At baseline, adults who developed AHOA were more likely to have hand pain (37% vs 22%), radiographic HOA (71% vs 36%), as well as central (22% vs 7%) and marginal erosions (11% vs 2%) in other joints compared to those without AHOA. Adults with AHOA were more likely to develop new erosions over 48 months (central 35%, marginal 5%) than those without AHOA (central 5%, marginal 1%). The most common locations of accelerated OA were the second metacarpophalangeal and first carpometacarpal joint.

conclusionAccelerated OA can occur in the hand, especially among digits commonly used for pinching and fine motor skills.

Indexed as

AgedCarpometacarpal JointsDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceMaleMetacarpophalangeal JointMiddle AgedOsteoarthritisPainRadiographyRisk FactorsThumbEPIDEMIOLOGYHANDOSTEOARTHRITIS

Identifiers

PMID30504506
PMCPMC6445673
OpenAlexW2903209851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.