Evidence map›Paper›PMID 30504365›Full record

ArticleGenetics2019

A New Tool for Inducible Gene Expression in

Gabriela C Monsalve, Keith R Yamamoto, Jordan D Ward

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Non-visual light modulates behavioral memory and gene expression inbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. TWISP: A Transgenic Worm for Interrogating Signal Propagation inbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Analysis of the C. elegans Germline Stem Cell Pool.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  11. Review
  12. A light sheet fluorescence microscopy protocol forFrontiers in cell and developmental biology · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. TheGenetics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gabriela C MonsalveDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158.ORCID 0000-0002-3866-8896
Keith R YamamotoDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158.ORCID 0000-0001-6766-335X
Jordan D WardDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 jward2@ucsc.edu.ORCID 0000-0001-9870-8936
University of California, San Francisco · USUniversity of California, Santa Cruz · US

Funding

GENE REGULATION BY STEROID RECEPTOR PROTEINSR01CA020535 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAMAMOTO, KEITH ROBERT · 1985 to 2018
$8.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Transcriptional networks controlling molting in C. elegans and B. malayiR00GM107345 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WARD, JORDAN DAVID · 2017 to 2019
$747k
Transporters for Glucocorticoids: Exploring a New Paradigm for Steroid Hormone Regulation, and a Potential Strategy for Identification of Toxin/Disruptor Transporter MachineriesR21ES026068 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAMAMOTO, KEITH ROBERT · 2015 to 2016
$436k
Transcriptional networks controlling molting in C. elegans and B. malayiK99GM107345 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WARD, JORDAN DAVID · 2014 to 2015
$180k
GENE REGULATION BY STEROID RECEPTOR PROTEINSR37CA020535 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI YAMAMOTO, KEITH ROBERT · 1990 to 1998
–
NCI NIH HHS R01 CA020535NCI NIH HHS R37 CA020535NIEHS NIH HHS R21 ES026068NIGMS NIH HHS K99 GM107345NIGMS NIH HHS R00 GM107345NIH HHS P40 OD010440
6 · The paper itself

Abstract

Controlling protein activity and localization is a key tool in modern biology. Mammalian steroid receptor ligand-binding domain (LBD) fusions have been used in a range of organisms and cell types to inactivate proteins of interest until the cognate steroid ligand is applied. Here, we demonstrate that the glucocorticoid receptor LBD confers ligand-gated control of a heterologous gene expression system (Q system) and the DAF-16 transcription factor in

Indexed as

Genetic TechniquesTranscriptional ActivationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDexamethasoneForkhead Transcription FactorsGlucocorticoidsHumansReceptors, GlucocorticoidCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDexamethasoneForkhead Transcription FactorsGlucocorticoidsReceptors, GlucocorticoidCaenorhabditis elegansdrug induciblegene expressionGlucocorticoid receptorligand-binding domain

Identifiers

PMID30504365
PMCPMC6366904
OpenAlexW2902928747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.