Evidence map›Paper›PMID 30504336›Full record

ReviewHematology. American Society of Hematology. Education Program2018

Autoimmune hemolytic anemia.

Anita Hill, Quentin A Hill

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Hematology. American Society of Hematology. Education Program, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04083014 (An Open, One-arm, Prospective Study of a Single Dose Anti-CD20 Monoclonal Antibody Combined With Bortezomib for Treatment of Relapsed Refractory Autoimmune Hemolytic Anemia), which is not on this map. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04083014 phase2completednot on this mapstarted 2019, after this paper: background citation

An Open, One-arm, Prospective Study of a Single Dose Anti-CD20 Monoclonal Antibody Combined With Bortezomib for Treatment of Relapsed Refractory Autoimmune Hemolytic Anemia

TypeinterventionalSponsorPeking Union Medical College HospitalRan2019 to 2024Enrolled33ConditionsAutoimmune Hemolytic Anemia, Autoimmune Hemolytic Anemia and Autoimmune ThrombocytopeniaArmscombination of a single dose anti-CD20 antibody and bortezomib
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Pooled it
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  3. Disease-modifying treatments for primary autoimmune haemolytic anaemia.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Pooled it
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  18. Cytopenias in Autoimmune Liver Diseases-A Review.Journal of clinical medicine · 2025
    Review
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  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anita HillDepartment of Haematology, Leeds Teaching Hospitals, Leeds, United Kingdom.
Quentin A HillDepartment of Haematology, Leeds Teaching Hospitals, Leeds, United Kingdom.
Leeds Teaching Hospitals NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of autoimmune hemolytic anemia (AIHA) can be made with a stepwise approach that aims to identify laboratory and clinical evidence of hemolysis and then determine the immune nature of hemolysis with the direct anti-globulin test. Once alternative causes for these findings have been excluded, AIHA is established, and the clinician must search for secondary causes, as well as identify the type of AIHA. Rituximab is now the preferred second-line treatment for primary warm AIHA and first-line treatment for primary cold agglutinin disease (CAD), either as monotherapy or combined with bendamustine. Complement inhibitors have shown utility in stabilizing AIHA patients with acute severe hemolysis. Future prospects are discussed and include the C1s inhibitor BIVV009 (sutimlimab) that is now entering phase 3 studies for CAD.

Indexed as

Anemia, Hemolytic, AutoimmuneClinical Trials, Phase III as TopicComplement Inactivating AgentsHumansRituximabComplement Inactivating AgentsRituximab

Identifiers

PMID30504336
PMCPMC6246027
OpenAlexW1843065013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.