Evidence map›Paper›PMID 30504243›Full record

ArticleMolecular & cellular proteomics : MCP2019

A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.

Anna Månberg, Frideborg Bradley, Ulrika Qundos, Brandon L Guthrie, Kenzie Birse, Laura Noël-Romas, Cecilia Lindskog, Rose Bosire, James Kiarie, Carey Farquhar and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. HIV-Exposed Seronegative Female Sex Workers Show Different Cellular Immune Profiles Across the Menstrual Cycle.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna MånbergFrom the ‡Affinity Proteomics, SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-0056-1313
Frideborg Bradley§Department of Medicine Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; frideborg.bradley@ki.se.ORCID 0000-0003-3006-7284
Ulrika QundosFrom the ‡Affinity Proteomics, SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden.
Brandon L Guthrie¶Department of Global Health and Department of Epidemiology Health, University of Washington, Seattle, Washington.
Kenzie Birse‖Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Laura Noël-Romas‖Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Cecilia Lindskog‡‡SciLifeLab, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Rose Bosire§§Kenya Medical Research Institute, Nairobi, Kenya.
James Kiarie¶¶Department of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Carey Farquhar‖‖Department of Medicine, Global Health, and Epidemiology, University of Washington, Seattle, Washington.
Adam D Burgener§Department of Medicine Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Peter NilssonFrom the ‡Affinity Proteomics, SciLifeLab, Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-4657-8532
Kristina Broliden§Department of Medicine Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2224-7664

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
Overcoming Barriers to HIV/AIDS Care and ART InitiationK01AI098527 · NIAID · UNIVERSITY OF WASHINGTON · PI GUTHRIE, BRANDON LODGE · 2012 to 2016
$647k
FIC NIH HHS D43 TW000007FIC NIH HHS R24 TW007988NIAID NIH HHS K01 AI098527NIAID NIH HHS K24 AI087399NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

Women at high risk of HIV infection, including sex workers and those with active genital inflammation, have molecular signatures of immune activation and epithelial barrier remodeling in samples of their genital mucosa. These alterations in the local immunological milieu are likely to impact HIV susceptibility. We here analyze host genital protein signatures in HIV uninfected women, with high frequency of condom use, living in HIV-serodiscordant relationships. Cervicovaginal secretions from women living in HIV-serodiscordant relationships (

Indexed as

AdultCervix UteriCluster AnalysisCornified Envelope Proline-Rich ProteinsCystatin BEarly DiagnosisElafinFemaleHigh-Throughput Screening AssaysHIV InfectionsHumansKallikreinsLongitudinal StudiesMaleMicrofilament ProteinsNuclear ProteinsCAPG protein, humanCornified Envelope Proline-Rich ProteinsCSTB protein, humanCystatin BElafinKallikreinsKLK10 protein, humanMicrofilament ProteinsNuclear ProteinsPI3 protein, humanSPRR3 protein, humanAffinity proteomicscervixfemale reproductive tractHIVHIV-serodiscordantImmunology*Inflammationreproductive immunologyTandem Mass Spectrometryvagina

Identifiers

PMID30504243
PMCPMC6398207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.