Evidence map›Paper›PMID 30504226›Full record

ArticleThe Journal of biological chemistry2019

Carolina Coelho, Lisa Brown, Maria Maryam, Raghav Vij, Daniel F Q Smith, Meagan C Burnet, Jennifer E Kyle, Heino M Heyman, Jasmine Ramirez, Rafael Prados-Rosales and 6 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 161 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Frontiers in bioinformatics · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. Listeria monocytogenes: from a saprophytic to a cytosolic virulent pathogen.World journal of microbiology & biotechnology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Carolina CoelhoW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205. Electronic address: carolina.coelho@abdn.ac.uk.
Lisa BrownDepartment of Microbiology and Immunology, Bronx, New York 10461.
Maria MaryamW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Raghav VijW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Daniel F Q SmithW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Meagan C BurnetBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352.
Jennifer E KyleBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352.
Heino M HeymanBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352.
Jasmine RamirezW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Rafael Prados-RosalesCIC bioGUNE, Derio, Bizkaia 48160, Spain.
Gregoire LauvauDepartment of Microbiology and Immunology, Bronx, New York 10461; Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461.
Ernesto S NakayasuBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352.
Nathan R BradyW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Anne Hamacher-BradyW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Isabelle CoppensW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205.
Arturo CasadevallW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205; Department of Microbiology and Immunology, Bronx, New York 10461; Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461. Electronic address: acasade1@jhu.edu.
Johns Hopkins University · USPacific Northwest National Laboratory · USAlbert Einstein College of Medicine · USCIC bioGUNE · ES

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Training Program In Cellular and Molecular MedicineT32GM135457 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAJINI RAO · 2020 to 2026
$5.4M
Enhancing Pathogen-specific Memory CD8+ T cell Responses in VivoR01AI103338 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAUVAU, GREGOIRE STEPHANE · 2013 to 2022
$5.2M
Molecular Characterization of C. neoformans AntibodiesR37AI033142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2007 to 2016
$3.9M
Medical Research Council MR/N006364/1NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI103338NIAID NIH HHS R37 AI033142NIGMS NIH HHS T32 GM008752NIGMS NIH HHS T32 GM135457
6 · The paper itself

Abstract

Outer membrane vesicles produced by Gram-negative bacteria have been studied for half a century but the possibility that Gram-positive bacteria secrete extracellular vesicles (EVs) was not pursued until recently due to the assumption that the thick peptidoglycan cell wall would prevent their release to the environment. However, following their discovery in fungi, which also have cell walls, EVs have now been described for a variety of Gram-positive bacteria. EVs purified from Gram-positive bacteria are implicated in virulence, toxin release, and transference to host cells, eliciting immune responses, and spread of antibiotic resistance.

Indexed as

AnimalsBacterial ToxinsCells, CulturedExtracellular VesiclesHeat-Shock ProteinsHemolysin ProteinsHemolysisHumansListeria monocytogenesListeriosisMacrophagesMCF-7 CellsMiceSheepVirulence FactorsBacterial ToxinsHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesVirulence Factorsexosome (vesicle)extracellular vesiclesGram-positive bacteriahemolysisListeria monocytogeneslisteriolysin OMPLExmultiomicsphospholipase Cvirulence factor

Identifiers

PMID30504226
PMCPMC6349127
OpenAlexW2902547680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.