Evidence map›Paper›PMID 30504223›Full record

ArticleThe Journal of biological chemistry2019

The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology.

Yuta Chiba, Bing He, Keigo Yoshizaki, Craig Rhodes, Muneaki Ishijima, Christopher K E Bleck, Erin Stempinski, Emily Y Chu, Takashi Nakamura, Tsutomu Iwamoto and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Transcriptional Regulation of Dental Epithelial Cell Fate.International journal of molecular sciences · 2020
    Review
  9. G protein-coupled receptorThe Journal of biological chemistry · 2020
    Article
  10. Article
  11. Expression Patterns ofFrontiers in cell and developmental biology · 2020
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 4 countries.

Yuta ChibaFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Bing HeFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Keigo YoshizakiFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Craig RhodesFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Muneaki IshijimaFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Christopher K E BleckElectron Microscopy Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892.
Erin StempinskiElectron Microscopy Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892.
Emily Y ChuLaboratory of Oral Connective Tissue Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, and.
Takashi NakamuraFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.ORCID 0000-0001-9904-1037
Tsutomu IwamotoFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Susana de VegaFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Kan SaitoDivision of Pediatric Dentistry, Department of Oral Health and Development Sciences and.
Satoshi FukumotoFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Yoshihiko YamadaFrom the Molecular Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, yoshi.yamada@nih.gov.
National Institutes of Health · USTohoku University · JP

Funding

Electron Microscopy CoreZICHL005906 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SYED, ZULFEQHAR · 2009 to 2025
$12.9M
Gene Transfer Core, NIDCR-DIRZICDE000744 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2014 to 2023
$12.1M
Oral and Craniofacial Development and DiseaseZIADE000720 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI YAMADA, YOSHIHIKO · 2009 to 2017
$6.1M
Intramural NIH HHS ZIA DE000720Intramural NIH HHS ZIC DE000744NIDCR NIH HHS ZIC DE000744
6 · The paper itself

Abstract

The development of ectodermal organs, such as teeth, requires epithelial-mesenchymal interactions. Basic helix-loop-helix (bHLH) transcription factors regulate various aspects of tissue development, and we have previously identified a bHLH transcription factor, AmeloD, from a tooth germ cDNA library. Here, we provide both

Indexed as

Cell MovementAmino Acid SequenceAnimalsCadherinsCell LineCell ProliferationEpithelial CellsGene Expression RegulationGene Knockout TechniquesMiceToothTranscription Factors, GeneralAscl5 protein, mouseCadherinsTranscription Factors, GeneralAmeloDbasic helix-loop-helix transcription factor (bHLH)cadherin-1 (CDH1)cell migrationectodermal organepiprofinepithelial cadherin (E-cadherin)epithelial-mesenchymal transition (EMT)gene knockoutinner enamel epitheliumtooth development

Identifiers

PMID30504223
PMCPMC6416439
OpenAlexW2902843165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.