Evidence map›Paper›PMID 30504221›Full record

ArticleThe Journal of biological chemistry2019

The antimicrobial activity of chemerin-derived peptide p4 requires oxidative conditions.

Urszula Godlewska, Bernadetta Bilska, Aneta Zegar, Piotr Brzoza, Arkadiusz Borek, Krzysztof Murzyn, Oliwia Bochenska, Agnieszka Morytko, Patryk Kuleta, Andrzej Kozik and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Chemerin-Derived Peptide ValFrontiers in microbiology · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Urszula GodlewskaDepartments of Immunology, 30-387 Kraków, Poland.
Bernadetta BilskaDepartment of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University, 30-387 Kraków, Poland.
Aneta ZegarDepartments of Immunology, 30-387 Kraków, Poland.
Piotr BrzozaDepartments of Immunology, 30-387 Kraków, Poland.
Arkadiusz BorekMolecular Biophysics, 30-387 Kraków, Poland.
Krzysztof MurzynComputational Biophysics and Bioinformatics, 30-387 Kraków, Poland.
Oliwia BochenskaAnalytical Biochemistry, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Agnieszka MorytkoDepartments of Immunology, 30-387 Kraków, Poland.
Patryk KuletaMolecular Biophysics, 30-387 Kraków, Poland.
Andrzej KozikAnalytical Biochemistry, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Elzbieta PyzaDepartment of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University, 30-387 Kraków, Poland.
Artur OsyczkaMolecular Biophysics, 30-387 Kraków, Poland.
Brian A ZabelPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304.
Joanna CichyDepartments of Immunology, 30-387 Kraków, Poland. Electronic address: Joanna.Cichy@uj.edu.pl.
University School of Physical Education in Kraków · PLJagiellonian University · PLPalo Alto Veterans Institute for Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemerin is a leukocyte attractant, adipokine, and antimicrobial protein abundantly produced in the skin epidermis. Despite the fact that most of the bactericidal activity present in human skin exudates is chemerin-dependent, just how chemerin shapes skin defenses remains obscure. Here we demonstrate that p4, a potent antimicrobial human chemerin peptide derivative, displays killing activity against pathogenic methicillin-resistant

Indexed as

AnimalsAnti-Bacterial AgentsChemokinesFemaleHumansIntercellular Signaling Peptides and ProteinsMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred C57BLMicrobial Sensitivity TestsOligopeptidesOxidation-ReductionOxidative StressSkinSkin Diseases, BacterialStaphylococcal InfectionsAnti-Bacterial AgentsChemokinesIntercellular Signaling Peptides and ProteinsOligopeptidespeptide P4RARRES2 protein, humanadipokineantimicrobial peptide (AMP)bacteriachemerinchemotaxisepidermishost defensehost–pathogen interactionMRSAskinStaphylococcus aureus (S. aureus)

Identifiers

PMID30504221
PMCPMC6349111
OpenAlexW2903148959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.