ArticleBiology open2019
Localized disorganization of the cochlear inner hair cell synaptic region after noise exposure.
Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea.iScience · 2024Article
- Noise-induced cochlear synaptopathy in C57BL/6 N mice as a function of trauma strength: ribbons are more vulnerable than postsynapses.Frontiers in cellular neuroscience · 2024Article
- Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells.Neuroscience bulletin · 2022Article
- MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea.Life science alliance · 2022Article
- Article
- A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma.Cell reports · 2021Article
- Maturation of Heterogeneity in Afferent Synapse Ultrastructure in the Mouse Cochlea.Frontiers in synaptic neuroscience · 2021Article
- Noise Exposure Potentiates Exocytosis From Cochlear Inner Hair Cells.Frontiers in synaptic neuroscience · 2021Article
- Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses-A Presynaptic Perspective.International journal of molecular sciences · 2020Review
- Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss.Neuroscience · 2020Article
- Article
- Audiometric notch for the prediction of early occupational hearing loss and its association with the interleukin-1beta genotype.Journal of Taibah University Medical Sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The prevalence and importance of hearing damage caused by noise levels not previously thought to cause permanent hearing impairment has become apparent in recent years. The damage to, and loss of, afferent terminals of auditory nerve fibres at the cochlear inner hair cell has been well established, but the effects of noise exposure and terminal loss on the inner hair cell are less known. Using three-dimensional structural studies in mice we have examined the consequences of afferent terminal damage on inner hair cell morphology and intracellular structure. We identified a structural phenotype in the pre-synaptic regions of these damaged hair cells that persists for four weeks after noise exposure, and demonstrates a specific dysregulation of the synaptic vesicle recycling pathway. We show evidence of a failure in regeneration of vesicles from small membrane cisterns in damaged terminals, resulting from a failure of separation of small vesicle buds from the larger cisternal membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.