Evidence map›Paper›PMID 30504071›Full record

Trial reportComprehensive psychiatry2019

An exploration of concomitant psychiatric disorders in children with autism spectrum disorder.

Luc Lecavalier, Courtney E McCracken, Michael G Aman, Christopher J McDougle, James T McCracken, Elaine Tierney, Tristram Smith, Cynthia Johnson, Bryan King, Benjamin Handen and 5 more

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Comprehensive psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Trial
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  5. Article
  6. Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Review
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  20. Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People.Journal of autism and developmental disorders · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Luc LecavalierOhio State University, Nisonger Center, United States of America. Electronic address: luc.Lecavalier@osumc.edu.
Courtney E McCrackenEmory University School of Medicine, Department of Pediatrics, United States of America. Electronic address: courtney.mccracken@emory.edu.
Michael G AmanOhio State University, Nisonger Center, United States of America. Electronic address: aman.1@osu.edu.
Christopher J McDougleLurie Center for Autism, Massachusetts General Hospital, United States of America. Electronic address: CMcDougle@partners.org.
James T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California at Los Angeles, United States of America. Electronic address: jmccracken@mednet.ucla.edu.
Elaine TierneyJohns Hopkins University School of Medicine, United States of America. Electronic address: tierney@kennedykrieger.org.
Tristram SmithUniversity of Rochester Medical Center, United States of America. Electronic address: Tristram_Smith@URMC.Rochester.edu.
Cynthia JohnsonCleveland Clinic and Learner College of Medicine, United States of America. Electronic address: johnsoc@ccf.org.
Bryan KingUniversity of California, San Francisco, Department of Psychiatry, Benioff Children's Hospitals, United States of America. Electronic address: bryan.king@ucsf.edu.
Benjamin HandenUniversity of Pittsburgh School of Medicine, United States of America. Electronic address: handenbl@upmc.edu.
Naomi B SwiezyHANDS in Autism Interdisciplinary Training and Resource Center, Indiana University School of Medicine, United States of America. Electronic address: nswiezy@iupui.edu.
L Eugene ArnoldOhio State University, Nisonger Center, United States of America. Electronic address: l.arnold@osumc.edu.
Karen BearssUniversity of Washington, Department of Psychiatry and Behavioral Sciences, United States of America. Electronic address: kbearss@u.washington.edu.
Benedetto VitielloDivision of Child and Adolescent Neuro-Psychiatry, University of Turin, Italy. Electronic address: bvitiell@unito.it.
Lawrence ScahillEmory University School of Medicine, Department of Pediatrics, United States of America. Electronic address: lawrence.scahill@emory.edu.

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
ZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RODRIGUEZ, HENRY · 1985 to 2008
$25.5M
YOGA, IMMUNE FUNCTION, AND HEALTHM01RR000034 · NCRR · OHIO STATE UNIVERSITY · PI PESAVENTO, TODD · 1985 to 2008
$22.7M
ZIPRASIDONE TREATMENT OF TOURETTE'S SYNDROME IN CHILDRENM01RR006022 · NCRR · YALE UNIVERSITY · PI KESSLER, DAVID A · 1990 to 2003
$6.7M
RUPP-PIU10MH066766 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MCDOUGLE, CHRISTOPHER J · 2002 to 2006
$2.7M
RUPP-PI Program at Yale UniversityU10MH066764 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2002 to 2006
$2.5M
RUPP-PI ProjectU10MH066768 · NIMH · OHIO STATE UNIVERSITY · PI AMAN, MICHAEL GEORGE · 2002 to 2006
$2.4M
2/3-Atomoxetine Placebo and Parent Training in AutismR01MH079080 · NIMH · OHIO STATE UNIVERSITY · PI AMAN, MICHAEL GEORGE · 2008 to 2012
$1.8M
Relapse Prevention: Long-Acting Atypical AntipsychoticsU01MH070010 · NIMH · UNIVERSITY OF IOWA · PI MILLER, DEL D · 2006 to 2010
$1.7M
3/3-Atomoxetine Placebo and Parent Training in AutismR01MH083247 · NIMH · UNIVERSITY OF ROCHESTER · PI SMITH, TRISTRAM H · 2008 to 2012
$1.4M
1/3-Atomoxetine Placebo and Parent Training in AutismR01MH079082 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2008 to 2012
$1.4M
4/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081221 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI SWIEZY, NAOMI BETH · 2010 to 2014
$1.2M
NCRR NIH HHS M01 RR000034NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR000750NCRR NIH HHS M01 RR006022NIDA NIH HHS N01 MH080011NIMH NIH HHS K24 MH001805NIMH NIH HHS R01 MH079080NIMH NIH HHS R01 MH079082NIMH NIH HHS R01 MH081105NIMH NIH HHS R01 MH081221NIMH NIH HHS R01 MH083247NIMH NIH HHS R01 MH083739NIMH NIH HHS U01 MH070009NIMH NIH HHS U01 MH070010NIMH NIH HHS U10 MH066764NIMH NIH HHS U10 MH066766NIMH NIH HHS U10 MH066768
6 · The paper itself

Abstract

objectiveWe explored patterns of concomitant psychiatric disorders in a large sample of treatment-seeking children and adolescents with autism spectrum disorder (ASD).

methodsParticipants were 658 children with ASD (age 3-17 years; mean = 7.2 years) in one of six federally-funded multisite randomized clinical trials (RCT) between 1999 and 2014. All children were referred for hyperactivity or irritability. Study designs varied, but all used the Child and Adolescent Symptom Inventory or Early Childhood Inventory to assess Attention Deficit Hyperactivity Disorder (ADHD), Oppositional-Defiant Disorder (ODD), Conduct Disorder (CD), Anxiety Disorders, and Mood Disorders. In addition, several measures in common were used to assess demographic and clinical characteristics.

resultsOf the 658 children, 73% were Caucasian and 59% had an IQ >70. The rates of concomitant disorders across studies were: ADHD 81%, ODD 46%, CD 12%, any anxiety disorder 42%, and any mood disorder 8%. Two or more psychiatric disorders were identified in 66% of the sample. Of those who met criteria for ADHD, 50% also met criteria for ODD and 46% for any anxiety disorder. Associations between types of concomitant disorders and a number of demographic and clinical characteristics are presented.

conclusionIn this well-characterized sample of treatment-seeking children with ASD, rates of concomitant psychiatric disorders were high and the presence of two or more co-occurring disorders was common. Findings highlight the importance of improving diagnostic practice in ASD and understanding possible mechanisms of comorbidity.

Indexed as

AdolescentAnxiety DisordersAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildChild, PreschoolComorbidityConduct DisorderFemaleHumansMaleMood DisordersAnxietyAttention deficit hyperactivity disorderAutism spectrum disorderComorbidityDisruptive behaviorPsychiatric disorder

Identifiers

PMID30504071
PMCPMC6295217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.