Evidence map›Paper›PMID 30503703›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019

Gray Matter Changes Associated With the Development of Delusions in Alzheimer Disease.

Winnie Qian, Tom A Schweizer, Nathan W Churchill, Colleen Millikin, Zahinoor Ismail, Eric E Smith, Lisa M Lix, David G Munoz, Joseph J Barfett, Tarek K Rajji and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  13. Delusions in Alzheimer Disease: What Researchers Should Not Forget.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Winnie QianKeenan Research Centre for Biomedical Research (WQ, TAS, NWC, DGM, JJB, CEF), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto; the Institute of Medical Sciences (WQ, TAS, TKR, CEF), University of Toronto, Toronto.
Tom A SchweizerKeenan Research Centre for Biomedical Research (WQ, TAS, NWC, DGM, JJB, CEF), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto; the Institute of Medical Sciences (WQ, TAS, TKR, CEF), University of Toronto, Toronto; the Institute of Biomaterials and Biomedical Engineering (TAS), University of Toronto, Toronto; the Department of Surgery (TAS), Division of Neurosurgery, Faculty of Medicine, University of Toronto, Toronto; the Division of Neurosurgery (TAS), St. Michael's Hospital, Toronto.
Nathan W ChurchillKeenan Research Centre for Biomedical Research (WQ, TAS, NWC, DGM, JJB, CEF), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto.
Colleen Millikinthe Department of Clinical Healthy Psychology (CM), College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Zahinoor Ismailthe Departments of Psychiatry and Neurology (ZI, EES), Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Eric E Smiththe Departments of Psychiatry and Neurology (ZI, EES), Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Lisa M Lixthe Department of Community Health Sciences (LML), College of Medicine, University of Manitoba, Winnipeg, Canada.
David G MunozKeenan Research Centre for Biomedical Research (WQ, TAS, NWC, DGM, JJB, CEF), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto; the Department of Laboratory Medicine and Pathobiology (DGM), University of Toronto, Toronto; the Division of Pathology (DGM), St. Michael's Hospital, Toronto.
Joseph J BarfettKeenan Research Centre for Biomedical Research (WQ, TAS, NWC, DGM, JJB, CEF), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto; the Department of Medical Imaging (JJB), St. Michael's Hospital, Toronto.
Tarek K Rajjithe Institute of Medical Sciences (WQ, TAS, TKR, CEF), University of Toronto, Toronto; the Campbell Family Mental Health Research Institute (TKR), Centre for Addiction and Mental Health, Toronto; the Temerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health (TKR), Toronto.
Corinne E FischerKeenan Research Centre for Biomedical Research (WQ, TAS, NWC, DGM, JJB, CEF), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto; the Institute of Medical Sciences (WQ, TAS, TKR, CEF), University of Toronto, Toronto; Department of Psychiatry (CEF), Faculty of Medicine, University of Toronto, Toronto. Electronic address: fischerc@smh.ca.
Institute of Medical Sciences · INSt. Michael's Hospital · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Toronto · CA

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHIMMING, CORBETT · 1985 to 2019
$37.9M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122
6 · The paper itself

Abstract

objectiveDelusions affect approximately a third of Alzheimer disease (AD) patients and are associated with poor outcomes. Previous studies investigating the neuroanatomic correlates of delusions have yet to reach a consensus, with findings of reduced volume across all lobes, particularly in frontal regions. The current study examined the gray matter (GM) differences associated with delusions in AD.

methodsUsing voxel-based morphometry, we assessed GM in 23 AD patients who developed delusions (AD+D) and 36 comparable AD patients who did not (AD-D) at baseline and follow-up. Analysis of variance was used to identify consistent differences between AD+D and AD-D patients across time points (main effect of group), consistent changes from baseline to follow-up (main effect of time), and differential changes between AD+D and AD-D over time (interaction of group and time). All data were obtained from the National Alzheimer's Coordinating Center database.

resultsThe AD+D group had consistently lower frontal GM volume, although both groups showed decreased GM in frontotemporal brain regions over time. An interaction was observed between delusions and longitudinal change, with AD+D patients having significantly elevated GM in predominantly temporal areas at baseline assessment, becoming significantly lower than the AD-D group at follow-up.

conclusionThese findings suggest that, there are specific volumetric markers that distinguish patients with delusions from those without, before, and after the onset of delusions. Specifically, the decline of GM in temporal areas that had elevated levels prior to the onset of delusions may be involved in the manifestation of delusions.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesDelusionsFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingSurveys and QuestionnairesAlzheimer diseasedelusionimagingpsychosisvoxel-based morphometry

Identifiers

PMID30503703
PMCPMC6777551
OpenAlexW2894852167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.