Evidence map›Paper›PMID 30503669›Full record

ArticleDNA repair2019

Correcting errors in the BRCA1 warning system.

Yanping Liang, William J Dearnaley, Nick A Alden, Maria J Solares, Brian L Gilmore, Kevin J Pridham, A Cameron Varano, Zhi Sheng, Elizabeth Alli, Deborah F Kelly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.Chembiochem : a European journal of chemical biology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yanping LiangVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA.
William J DearnaleyVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, 16802, USA; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA; Center for Structural Oncology, Pennsylvania State University, University Park, PA, 16802, USA.
Nick A AldenVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA.
Maria J SolaresVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA; Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, VA, 24061, USA.
Brian L GilmoreVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA.
Kevin J PridhamVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA; Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, VA, 24061, USA.
A Cameron VaranoVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA; Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, VA, 24061, USA; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, 16802, USA; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA; Center for Structural Oncology, Pennsylvania State University, University Park, PA, 16802, USA.
Zhi ShengVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA.
Elizabeth AlliComprehensive Cancer Center, Wake Forest School of Medicine, Wake Forest, NC, 27157, USA.
Deborah F KellyVirgina Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia, 24016, USA; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, 16802, USA; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA; Center for Structural Oncology, Pennsylvania State University, University Park, PA, 16802, USA. Electronic address: debkelly@vt.edu.
Carilion Clinic · USPennsylvania State University · USWake Forest University · US

Funding

Multi-scale imaging of breast cancer proteins during DNA repairR01CA219700 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KELLY, DEBORAH F · 2018 to 2022
$2.1M
Hot Spot Analysis of the Breast Cancer Susceptibility ProteinR01CA227261 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KELLY, DEBORAH F · 2018 to 2022
$2.0M
Tunable Microchip Sorting of BRCA1 Nuclear AssembliesR01CA193578 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KELLY, DEBORAH F · 2015 to 2020
$1.8M
Targeting defective DNA repair for the prevention of BRCA1-associated cancersK22CA181550 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLI, ELIZABETH · 2015 to 2017
$486k
NCI NIH HHS K22 CA181550NCI NIH HHS R01 CA193578NCI NIH HHS R01 CA219700NCI NIH HHS R01 CA227261
6 · The paper itself

Abstract

Given its important role in human health and disease, remarkably little is known about the full-length three-dimensional (3D) molecular architecture of the breast cancer type 1 susceptibility protein (BRCA1), or its mechanisms to engage the tumor suppressor, TP53 (p53). Here, we show how a prevalent cancer-related mutation in the C-terminal region of the full-length protein, BRCA1

Indexed as

MutationBRCA1 ProteinCell Line, TumorDNA Breaks, Double-StrandedDNA RepairHumansModels, MolecularProtein ConformationTumor Suppressor Protein p53BRCA1 ProteinBRCA1 protein, humanTumor Suppressor Protein p53BRCA1Breast cancerElectron microscopyp53Structural biologyUbiquitin

Identifiers

PMID30503669
PMCPMC6375096
OpenAlexW2900684532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.