ArticleCell systems2018
Temperature Sensing Is Distributed throughout the Regulatory Network that Controls FLC Epigenetic Silencing in Vernalization.
Article in Cell systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Locally adapted Arabidopsis thaliana accessions show transcriptomic plasticity in a multi-timescale analysis of whole-genome gene expression in a natural environment.Plant biology (Stuttgart, Germany) · 2026Article
- Cold hardiness mechanisms and modeling: existing approaches and future avenues.The New phytologist · 2026Review
- Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.Frontiers in plant science · 2026Review
- Seasonal timing in a changing world: the epigenetic link between environment and reproduction across taxa.Environmental epigenetics · 2026Article
- Seasons and shape: inflorescences from autumn to summer.Journal of experimental botany · 2025Review
- SlimVar for rapid in vivo single-molecule tracking of chromatin regulators in plants.Nature communications · 2025Article
- Transcriptional regulation of SlFRIGIDA-like improve antioxidant system in tomato under cold.BMC plant biology · 2025Article
- Advancing ecological and evolutionary research in Arabidopsis: Extending insights into model and nonmodel plants.The Plant cell · 2025Review
- Plant ADH1 promoter acts as an H3K27me3-associated hyper-long cold-responsive promoter.The Plant journal : for cell and molecular biology · 2025Article
- Stress sensing and response through biomolecular condensates in plants.Plant communications · 2025Review
- Transcription factor VRT2 reinitiates vernalization when interrupted by warm temperatures in a temperate grass model.Plant physiology · 2024Article
- Review
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- Article
- Article
- Plant environmental memory: implications, mechanisms and opportunities for plant scientists and beyond.AoB PLANTS · 2023Review
- Article
- Genome-Wide Identification and Analysis of theGenes · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Many organisms need to respond to complex, noisy environmental signals for developmental decision making. Here, we dissect how Arabidopsis plants integrate widely fluctuating field temperatures over month-long timescales to progressively upregulate VERNALIZATION INSENSITIVE3 (VIN3) and silence FLOWERING LOCUS C (FLC), aligning flowering with spring. We develop a mathematical model for vernalization that operates on multiple timescales-long term (month), short term (day), and current (hour)-and is constrained by experimental data. Our analysis demonstrates that temperature sensing is not localized to specific nodes within the FLC network. Instead, temperature sensing is broadly distributed, with each thermosensory process responding to specific features of the plants' history of exposure to warm and cold. The model accurately predicts FLC silencing in new field data, allowing us to forecast FLC expression in changing climates. We suggest that distributed thermosensing may be a general property of thermoresponsive regulatory networks in complex natural environments.
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Registered trials
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