Evidence map›Paper›PMID 30503609›Full record

Observational studyJournal of voice : official journal of the Voice Foundation2020

Biobehavioral Measures of Presbylaryngeus.

Vrushali Angadi, Colleen McMullen, Richard Andreatta, Maria Dietrich, Tim Uhl, Joseph Stemple

Abstract readObservational Study
In one paragraph

Observational study in Journal of voice : official journal of the Voice Foundation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vrushali AngadiDivision of Communication Sciences and Disorders, University of Kentucky, Lexington, Kentucky. Electronic address: vrushali.angadi@gmail.com.
Colleen McMullenDepartment of Cardiology and Physiology, University of Kentucky, Lexington, Kentucky.
Richard AndreattaDivision of Communication Sciences and Disorders, University of Kentucky, Lexington, Kentucky.
Maria DietrichSpeech, Language and Hearing Sciences, University of Missouri, Columbia, Missouri.
Tim UhlRehabilitation Sciences, University of Kentucky, Lexington, Kentucky.
Joseph StempleDivision of Communication Sciences and Disorders, University of Kentucky, Lexington, Kentucky.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Response of aging intrinsic laryngeal muscles to chronic electrical stimulationR01DC011285 · NIDCD · UNIVERSITY OF KENTUCKY · PI MCMULLEN, COLLEEN A · 2011 to 2015
$1.6M
Exogenous growth factors for reversal of age-related laryngeal muscle denervationR21DC010806 · NIDCD · UNIVERSITY OF KENTUCKY · PI MCMULLEN, COLLEEN A, STEMPLE, JOSEPH · 2010 to 2011
$402k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NIDCD NIH HHS R01 DC011285NIDCD NIH HHS R21 DC010806
6 · The paper itself

Abstract

objectiveThe objective of this observational study was to assess the relationship between established aging biobehavioral measures and voice decline in normally aging adults. STUDY

designCross-sectional study.

methodsParticipants 60-85 years of age were divided into two age and sex-matched groups, based on the presence or absence of presbylaryngeus. Both groups underwent a battery of tests measuring anthropometric variables, inflammatory markers, general health measures, and vocal function parameters. Differences from the norm were calculated for all variables. Parametric and nonparametric tests were performed to assess group differences. In addition, variable selection analysis was performed to determine variables that were most influential in predicting the occurrence of presbylaryngeus in our current sample.

resultsFifty-three participants were divided into age and sex-matched groups of "presbylaryngeus" (n = 26) and "non-presbylaryngeus" (n = 27). The two groups were statistically different in select measures of inflammatory markers, general health measures, and vocal function parameters. Anthropometric measures were not statistically different. Based on variable selection, the variables most predictive of the presence of presbylaryngeus were measures of the Physical Activity Scale of the Elderly, C-reactive protein, laryngeal airway resistance, and vocal roughness.

conclusionsIn addition to group differences in vocal function measures, results for the presbylaryngeus group consistently trended sub-optimally on anthropometric measures, two inflammatory markers, and general health measures. These results suggest that this sample of individuals with presbylaryngeus demonstrated greater biobehavioral deficits associated with aging as compared to age and sex-matched non-presbylaryngeus individuals.

Indexed as

AgingGeriatric AssessmentVoice QualityAcousticsAgedAged, 80 and overAge FactorsAirway ResistanceAnthropometryBiomarkersCase-Control StudiesFemaleFunctional StatusHumansInflammation MediatorsMaleBiomarkersInflammation MediatorsAgingBiobehavioral measuresPresbylaryngeusVoice

Identifiers

PMID30503609
PMCPMC6541560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.