ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2019
ZnO nanoparticles affect nutrient transport in an in vitro model of the small intestine.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Analytical challenges in the assessment of intestinal fate, uptake and crossing of food-relevant nanomaterials.Mikrochimica acta · 2026Review
- Nanoparticle Uptake and Crossing by Human In Vitro Models of Intestinal Barriers: A Scoping Review.Nanomaterials (Basel, Switzerland) · 2025Review
- Small Intestine on a Chip Demonstrates Physiologic Mucus Secretion in the Presence of Lacticaseibacillus rhamnosus Biofilm.Biotechnology and bioengineering · 2025Article
- Effects of Dietary Supplementation of Zinc Oxide Quantum Dots on Growth Performance and Gut Health in Broilers.Biological trace element research · 2025Article
- Last Fifteen Years of Nanotechnology Application with Our Contribute.Nanomaterials (Basel, Switzerland) · 2025Review
- The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function.International journal of molecular sciences · 2024Review
- An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption.Frontiers in toxicology · 2024Article
- The Effect of Dietary Zinc Oxide Nanoparticles on Growth Performance, Zinc in Tissues, and Immune Response in the Rare Minnow (Aquaculture nutrition · 2024Article
- Food-Grade Metal Oxide Nanoparticles Exposure Alters Intestinal Microbial Populations, Brush Border Membrane Functionality and Morphology, In Vivo (Antioxidants (Basel, Switzerland) · 2023Article
- The mechanistic effects of human digestion on magnesium oxide nanoparticles: implications for probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium bifidum VPI 1124.Environmental science. Nano · 2022Article
- Impact of in vitro digested zinc oxide nanoparticles on intestinal model systems.Particle and fibre toxicology · 2022Article
- Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women.Scientific reports · 2022Article
- Article
- Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells.Toxics · 2021Article
- The Role of Metal Oxide Nanoparticles,Environmental science. Nano · 2020Article
- Recent insights on indirect mechanisms in developmental toxicity of nanomaterials.Particle and fibre toxicology · 2020Review
- A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models.Nutrients · 2020Review
- Intra-amniotic administration (Gallus gallus) of TiOFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Article
- Toxicity of combined exposure of ZnO nanoparticles (NPs) and myricetin to Caco-2 cells: changes of NP colloidal aspects, NP internalization and the apoptosis-endoplasmic reticulum stress pathway.Toxicology research · 2019Article
- Influence of 3-Hydroxyflavone on Colloidal Stability and Internationalization of Ag Nanomaterials Into THP-1 Macrophages.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Nano-sized zinc oxide (ZnO) is present in food packaging, putting consumers at risk of ingestion. There is little information on the amount of ZnO nanoparticles (NP) present in food packaging and the effects of ZnO NP ingestion on intestinal function. To estimate physiologically relevant ZnO NP exposures from food that are commonly packaged with ZnO NP, food samples were analyzed with inductively coupled plasma mass spectrometry (ICP-MS). An in vitro model of the small intestine was used to investigate the effects of ZnO NP exposure. Cells were exposed to pristine NP in culture medium and to NP subjected to an in vitro digestion process to better reflect the transformation that the NP undergo in the human gastrointestinal (GI) tract. The findings show that a physiologically relevant dose of ZnO NP can cause a significant decrease in glucose transport, which is consistent with gene expression changes for the basolateral glucose transporter GLUT2. There is also evidence that the ZnO NP affect the microvilli of the intestinal cells, therefore reducing the amount of surface area available to absorb nutrients. These results suggest that the ingestion of ZnO NP can alter nutrient absorption in an in vitro model of the human small intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.