ArticleCell2019
Low-Fidelity Assembly of Influenza A Virus Promotes Escape from Host Cells.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Cryo-electron tomography of Nipah virus structural protein complexes in virus-like particles.bioRxiv : the preprint server for biology · 2026Article
- Filamentous morphology of influenza A virus confers enhanced stability in aerosols.Nature communications · 2026Article
- Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities.PLoS pathogens · 2026Article
- Implications of morphological variation in influenza viruses.Microbiology and molecular biology reviews : MMBR · 2025Review
- Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin.Journal of virology · 2025Article
- Morphology-dependent entry kinetics and spread of influenza A virus.The EMBO journal · 2025Article
- A physical model for M1-mediated influenza A virus assembly.Biophysical journal · 2025Article
- Live-Cell Single-Molecule Imaging of Influenza A Virus-Receptor Interaction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Single Extracellular Vesicle Imaging and Computational Analysis Identifies Inherent Architectural Heterogeneity.ACS nano · 2024Article
- Can iron chelators ameliorate viral infections?Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- The pathogenesis of influenza in intact alveoli: virion endocytosis and its effects on the lung's air-blood barrier.Frontiers in immunology · 2024Review
- Machine learning for cross-scale microscopy of viruses.Cell reports methods · 2023Review
- Neuraminidase Activity Modulates Cellular Coinfection during Influenza A Virus Multicycle Growth.mBio · 2023Article
- High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization.PLoS pathogens · 2023Article
- Receptor Density-Dependent Motility of Influenza Virus Particles on Surface Gradients.ACS applied materials & interfaces · 2023Article
- Cholesterol and M2 Rendezvous in Budding and Scission of Influenza A Virus.Sub-cellular biochemistry · 2023Article
- The evolutionary potential of influenza A virus hemagglutinin is highly constrained by epistatic interactions with neuraminidase.Cell host & microbe · 2022Article
- A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.Microbiology and molecular biology reviews : MMBR · 2022Review
- Hemagglutinin Stability Determines Influenza A Virus Susceptibility to a Broad-Spectrum Fusion Inhibitor Arbidol.ACS infectious diseases · 2022Article
- How Can We Resolve Lewontin's Paradox?Genome biology and evolution · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Influenza viruses inhabit a wide range of host environments using a limited repertoire of protein components. Unlike viruses with stereotyped shapes, influenza produces virions with significant morphological variability even within clonal populations. Whether this tendency to form pleiomorphic virions is coupled to compositional heterogeneity and whether it affects replicative fitness remains unclear. Here, we address these questions by developing a strain of influenza A virus amenable to rapid compositional characterization through quantitative, site-specific labeling of viral proteins. Using this strain, we find that influenza A produces virions with broad variations in size and composition from even single infected cells. This phenotypic variability contributes to virus survival during environmental challenges, including exposure to antivirals. Complementing genetic adaptations that act over larger populations and longer times, this "low-fidelity" assembly of influenza A virus allows small populations to survive environments that fluctuate over individual replication cycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.