ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2019
Impact of multiplex molecular assay turn-around-time on antibiotic utilization and clinical management of hospitalized children with acute respiratory tract infections.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A pragmatic randomized controlled trial of rapid on-site influenza and respiratory syncytial virus PCR testing in paediatric and adult populations.BMC infectious diseases · 2022Trial
- Microbial Detection in Community-Acquired Pleural Space Infections Using the BIOFIRE Joint Infection Panel and Individual Polymerase Chain Reaction Assays.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Article
- Rapid diagnosis of acute pediatric respiratory infections with Point-of-Care and multiplex molecular testing.Infection · 2025Review
- Incidence of common respiratory pathogens among patients with severe acute respiratory infection during COVID-19 pandemic in Egypt.Scientific reports · 2025Article
- State of the Art of Antimicrobial and Diagnostic Stewardship in Pediatric Setting.Antibiotics (Basel, Switzerland) · 2025Review
- A descriptive study on feasibility of nasopharyngeal and oropharyngeal swab collection from pediatric research participants in Cebu, Philippines.Frontiers in public health · 2025Observational
- Viral etiology of severe acute respiratory infections in hospitalized patients, Shandong, China.PloS one · 2025Observational
- Factors associated with tracheostomy-associated infection treatment: A multicenter observational study.Pediatric pulmonology · 2024Observational
- Exploring the Impact of Antibiotics on Fever Recovery Time and Hospital Stays in Children with Viral Infections: Insights from Advanced Data Analysis.Antibiotics (Basel, Switzerland) · 2024Article
- Multiplex PCR and Antibiotic Use in Children with Community-Acquired Pneumonia.Children (Basel, Switzerland) · 2024Article
- Outcomes of viral coinfections in infants hospitalized for acute bronchiolitis.Virology journal · 2023Observational
- An economic evaluation of two PCR-based respiratory panel assays for patients admitted to hospital with community-acquired pneumonia (CAP) in the UK, France and Spain.BMC pulmonary medicine · 2023Article
- Antibiotic Use and Respiratory Viral PCR Testing Among Pediatric Patients With Nosocomial Fever.Cureus · 2023Article
- Clinical Characteristics Associated with Detected Respiratory Microorganism Employing Multiplex Nested PCR in Patients with Presumptive COVID-19 but Negative Molecular Results in Lima, Peru.Tropical medicine and infectious disease · 2022Article
- Point-of-Care and Rapid Tests for the Etiological Diagnosis of Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- Comparative Performance of the Luminex NxTAG Respiratory Pathogen Panel, GenMark eSensor Respiratory Viral Panel, and BioFire FilmArray Respiratory Panel.Microbiology spectrum · 2022Article
- Antimicrobial stewardship program in pediatric medicine.Pediatric investigation · 2021Review
- Predictive Antibiotic Susceptibility Testing by Next-Generation Sequencing for Periprosthetic Joint Infections: Potential and Limitations.Biomedicines · 2021Review
- Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China.BMC pediatrics · 2021Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEmpiric antibiotic treatment is common among children with acute respiratory tract infections (ARTI), despite infections being predominately viral. The use of molecular respiratory panel assays has become increasingly common for medical care of patients with ARTIs. STUDY
designThis was a 6-year retrospective, single-centered study of pediatric inpatients who tested positive for an ARTI respiratory pathogen. We examined the relationship between clinical outcomes and whether the patient was tested using the Luminex Respiratory Viral Panel ([RVP]; in-use: Dec. 2009 - Jul. 2012) or Biofire Respiratory Pathogen Panel ([RP]; in-use Aug. 2012 - Jun. 2016). The prevalence and duration of pre-test empiric antibiotics, post-test oseltamivir administration to influenza patients, chest x-rays and length of stay between the two assays was compared.
resultsA total of 5142 patients (1264 RVP; 3878 RP) were included. The median laboratory turn-around-time for RP was significantly shorter than RVP (1.4 vs. 27.1 h, respectively; p < .001). Patients tested with RP were less likely to receive empiric antibiotics (OR: 0.45; p < .001; 95% CI: 0.39, 0.52) and had a shorter duration of empiric broad-spectrum antibiotics (6.4 h vs. 32.9 h; p < .001) compared to RVP patients. RP influenza patients had increased oseltamivir use post- test compared to RVP influenza patients (OR: 13.56; p < .001; 95% CI: 7.29, 25.20).
conclusionsRapid molecular testing positively impacts patient management of ARTIs. Adopting assays with a shorter turn-around-time improves decision making by decreasing empirical antibiotic use and duration, decreasing chest x-rays, increasing timely oseltamivir administration, and reducing length of stay.
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