Evidence map›Paper›PMID 30502155›Full record

ArticleFood chemistry2019

Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities.

Mary H Grace, Jia Xiong, Debora Esposito, Mark Ehlenfeldt, Mary Ann Lila

Abstract read
In one paragraph

Article in Food chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
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  4. Article
  5. Production of Lambic-like Fruit Sour Beer withAntioxidants (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
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  10. Article
  11. Drying: A Practical Technology for Blueberries (Antioxidants (Basel, Switzerland) · 2024
    Article
  12. Article
  13. Screening of MMolecules (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mary H GracePlants for Human Health Institute, Food Bioprocessing, and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus, NC, USA.
Jia XiongPlants for Human Health Institute, Food Bioprocessing, and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus, NC, USA.
Debora EspositoPlants for Human Health Institute, Animal Sciences Department, North Carolina State University, North Carolina Research Campus, NC, USA.
Mark EhlenfeldtGenetic Improvement of Fruits and Vegetables Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Marucci Center for Blueberry and Cranberry Research & Extension, Rutgers University, Chatsworth, NJ, USA.
Mary Ann LilaPlants for Human Health Institute, Food Bioprocessing, and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus, NC, USA. Electronic address: mlila@ncsu.edu.

Funding

Berries and BonesR01AT008754 · NCCIH · PURDUE UNIVERSITY · PI FORMAN, MICHELE ROBIN · 2014 to 2018
$3.9M
NCCIH NIH HHS R01 AT008754
6 · The paper itself

Abstract

A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple (Vaccinium angustifolium) to various shades of pink (crosses of V. corymbosum, V. darrowii, and V. ashei). Standard calibration curves were linear for all analytes with correlation coefficients >0.99. The relative standard deviation for intra- and inter-day precision was lower than 10%. The method allowed an easy and selective identification and quantification of phenolics in blueberries with divergent profiles. The in vitro antioxidant assay results were strongly correlated with total phenolics and total anthocyanin content. Lowbush blueberry extracts (50 μg/mL) reduced ROS and NO production, and inhibited the transcription of the proinflammatory cytokines IL-6β, COX2, iNOS, and IL-6 in the in vitro assays at much lower concentrations than pink fruited berries (250 μg/mL).

Indexed as

AnimalsAnthocyaninsAnti-Inflammatory AgentsAntioxidantsBiological AssayBlueberry PlantsCell SurvivalChromatography, LiquidColorFlavonoidsFlavonolsFruitHydroxybenzoatesLimit of DetectionMass SpectrometryMiceAnthocyaninsAnti-Inflammatory AgentsAntioxidantsflavan-3-olFlavonoidsFlavonolsHydroxybenzoatesNitric Oxidephenolic acidPhenolsPlant ExtractsReactive Oxygen SpeciesResveratrolAnti-inflammatoryAntioxidantBlueberriesLC-IT-TOF-MSPCAPink-fruitedQuantification

Identifiers

PMID30502155
PMCPMC6287264

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.