ArticleBiological psychiatry2019
Value-Based Choice, Contingency Learning, and Suicidal Behavior in Mid- and Late-Life Depression.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Self-injurious thoughts and behaviors and alterations in positive valence systems: A systematic review of the literature.Journal of psychiatric research · 2022Pooled it
- When to quit: Calibration of voluntary persistence and attempted suicide in depression.Behaviour research and therapy · 2026Article
- Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity.Human brain mapping · 2026Article
- Risk, reward, and suicide: how impulsivity and loss aversion influence decision-making in individuals who have attempted suicide.Frontiers in psychiatry · 2026Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Past suicide attempt is associated with a weaker decision-making bias to actively escape from suicide-related stimuli.Journal of psychopathology and clinical science · 2025Article
- Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Suicidal urges and attempted suicide at multiple time scales in borderline personality disorder.Journal of affective disorders · 2023Article
- Correlation Between Sleep Electroencephalogram, Brain-Derived Neurotrophic Factor, AVPR1B Gene Polymorphism, and Suicidal Behavior in Patients with Depression.Applied biochemistry and biotechnology · 2023Article
- Dissociated deficits of anticipated and experienced regret in at-risk suicidal individuals.Frontiers in psychiatry · 2023Article
- Suicide prevention and ketamine: insights from computational modeling.Frontiers in psychiatry · 2023Review
- Work Expectations, Depressive Symptoms, and Passive Suicidal Ideation Among Older Adults: Evidence From the Health and Retirement Study.The Gerontologist · 2022Article
- Can cognition help predict suicide risk in patients with major depressive disorder? A machine learning study.BMC psychiatry · 2022Article
- Negative affectivity and disinhibition as moderators of an interpersonal pathway to suicidal behavior in borderline personality disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Decision neuroscience and neuroeconomics: Recent progress and ongoing challenges.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Search for solutions, learning, simulation, and choice processes in suicidal behavior.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- A Computational Model of Hopelessness and Active-Escape Bias in Suicidality.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Delay discounting in suicidal behavior: Myopic preference or inconsistent valuation?Journal of psychopathology and clinical science · 2022Article
- Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Neurocomputational mechanism of controllability inference under a multi-agent setting.PLoS computational biology · 2021Article
Corrections and comments
- Erratum issuedErratum.2019
Authors and funding
5 authors.
Funding
Abstract
backgroundSuicidal behavior is associated with impaired decision making in contexts of uncertainty. Existing studies, however, do not definitively address whether suidice attempers have 1) impairment in learning from experience or 2) impairment in choice based on comparison of estimated option values. Our reinforcement learning model-based behavioral study tested these hypotheses directly in middle-aged and older suicide attempters representative of those who die by suicide.
methodsTwo samples (sample 1, n = 135; sample 2, n = 125) of suicide attempters with depression (n
resultsWith regard to learning, suicide attempters (vs. all comparison groups) were less sensitive to one-back reinforcement, as indicated by a reduced effect on both choices and decision times. Learning deficits scaled with attempt lethality and were partially explained by poor cognitive control. With regard to value-based choice, suicide attempters (vs. all comparison groups) displayed abnormally long decision times when choosing between similarly valued options and were less able to distinguish between the best and second-best options. Group differences in value-based choice were robust to controlling for cognitive performance, comorbidities, impulsivity, psychotropic exposure, and possible brain damage from attempts.
conclusionsSerious suicidal behavior is associated with impaired reward learning, likely undermining the search for alternative solutions. Attempted suicide is associated with impaired value comparison during the choice process, potentially interfering with the consideration of deterrents and alternatives in a crisis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.