Evidence map›Paper›PMID 30502044›Full record

ArticleNeuron2019

High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays.

Jason E Chung, Hannah R Joo, Jiang Lan Fan, Daniel F Liu, Alex H Barnett, Supin Chen, Charlotte Geaghan-Breiner, Mattias P Karlsson, Magnus Karlsson, Kye Y Lee and 7 more

Abstract read
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  12. Friend, Not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Article
  14. Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jason E ChungMedical Scientist Training Program and Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: jason.chung@ucsf.edu.
Hannah R JooMedical Scientist Training Program and Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Jiang Lan FanBioengineering Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel F LiuKavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Bioengineering Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Alex H BarnettCenter for Computational Biology, Flatiron Institute, 162 Fifth Avenue, New York, NY 10010, USA.
Supin ChenCenter for Micro- and Nano-Technology, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Charlotte Geaghan-BreinerKavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Mattias P KarlssonSpikeGadgets LLC, San Francisco, CA 94158, USA.
Magnus KarlssonSpikeGadgets LLC, San Francisco, CA 94158, USA.
Kye Y LeeCenter for Micro- and Nano-Technology, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Hexin LiangKavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Jeremy F MaglandCenter for Computational Biology, Flatiron Institute, 162 Fifth Avenue, New York, NY 10010, USA.
Jeanine A PebblesCenter for Micro- and Nano-Technology, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Angela C TookerCenter for Micro- and Nano-Technology, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Leslie F GreengardCenter for Computational Biology, Flatiron Institute, 162 Fifth Avenue, New York, NY 10010, USA; Courant Institute, NYU, New York, NY 10012, USA.
Vanessa M TolosaCenter for Micro- and Nano-Technology, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Loren M FrankKavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, San Francisco, CA, USA. Electronic address: loren@phy.ucsf.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Modular systems for measuring brain activity in primatesU01NS090537 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANK, LOREN M, HARRISON, REID · 2014 to 2016
$2.6M
Memory and memory confidence in the hippocampus and orbitofrontal cortexF30MH115582 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOO, HANNAH · 2017 to 2020
$162k
Hippocampal-prefrontal interactions during memory-guided decision makingF30MH109292 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHUNG, JASON ERN-CHI · 2015 to 2017
$106k
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM007618NIMH NIH HHS F30 MH109292NIMH NIH HHS F30 MH115582NINDS NIH HHS U01 NS090537
6 · The paper itself

Abstract

The brain is a massive neuronal network, organized into anatomically distributed sub-circuits, with functionally relevant activity occurring at timescales ranging from milliseconds to years. Current methods to monitor neural activity, however, lack the necessary conjunction of anatomical spatial coverage, temporal resolution, and long-term stability to measure this distributed activity. Here we introduce a large-scale, multi-site, extracellular recording platform that integrates polymer electrodes with a modular stacking headstage design supporting up to 1,024 recording channels in freely behaving rats. This system can support months-long recordings from hundreds of well-isolated units across multiple brain regions. Moreover, these recordings are stable enough to track large numbers of single units for over a week. This platform enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale evolution of anatomically distributed circuits, and thereby provides a new tool for understanding brain activity.

Indexed as

AnimalsBrainElectrodes, ImplantedElectrophysiological PhenomenaMaleNerve NetPolymersRatsRats, Long-EvansPolymersfreely behavingheadstagemassively parallelmodularmulti-electrode recordingpolymerproberatsingle neuronspike sorting

Identifiers

PMID30502044
PMCPMC6326834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.