ArticleBMC musculoskeletal disorders2018
Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between adipokine levels and bone mass-A systematic review.Endocrinology, diabetes & metabolism · 2023Pooled it
- Positive correlation between IL-6 levels and lumbar bone mineral density in menopausal women diagnosed with osteoporosis in comparison to menopausal women without osteoporosis.BMC research notes · 2026Article
- Association of inflammatory markers and multimorbidity in young adults: cross-sectional findings from the Pelotas (Brazil) birth cohort, 1993.Cadernos de saude publica · 2025Article
- Prediction of Osteoporotic Hip Fracture Outcome: Comparative Accuracy of 27 Immune-Inflammatory-Metabolic Markers and Related Conceptual Issues.Journal of clinical medicine · 2024Article
- Evaluation of vitamin D deficiency and low bone mass in children with asthma in fars province: A case-control study.Health science reports · 2024Article
- Individual Trajectories of Bone Mineral Density Reveal Persistent Bone Loss in Bone Sarcoma Patients: A Retrospective Study.Journal of clinical medicine · 2022Article
- High-sensitivity C-reactive protein could be a potential indicator of bone mineral density in adolescents aged 10-20 years.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundStudies have shown that cytokines play a role in bone remodeling.
methodsIn 1993, all hospital births occurred in Pelotas (Brazil) were identified and a total of 5249 newborns were included in the present cohort. Sub-samples of this cohort were visited during childhood and all members were traced at 11, 15, 18 and 22 years old. At 18 and 22 years the following biomarkers were measured: IL-6, CRP and adiponectin (the last one in a sub-sample) and bone mineral density (BMD-mg/cm
resultsNo statistical significant association was found between IL-6 and CRP with BMD, in males. Significant inverse association in the adjusted analysis, among females, was found for the highest tertiles of CRP at 22 y (beta - 15.2 mg/cm
conclusionCRP at 22 years, in females, seems to be a marker for total body BMD; adiponectin at 22 years is also a marker for BMD at the three sites, in males, and for lumbar spine BMD, in females.
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