Evidence map›Paper›PMID 30501618›Full record

Trial reportBMC musculoskeletal disorders2018

Perioperative multiple low-dose Dexamethasones improves postoperative clinical outcomes after Total knee arthroplasty.

Yuangang Wu, Xiaoxi Lu, Yimei Ma, Yi Zeng, Xianchao Bao, Huazhang Xiong, Bin Shen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04738318 (Steroid Administration for Articular Fractures of the Elbow), which is not on this map. Cited by 18 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 7 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04738318 phase4terminatednot on this mapstarted 2022, after this paper: background citation

Steroid Administration for Articular Fractures of the Elbow (SAFE Trial): A Randomized, Controlled Trial of Perioperative Glucocorticoids During Treatment of Intraarticular Elbow Fractures

TypeinterventionalSponsorVanderbilt University Medical CenterRan2022 to 2023Enrolled3ConditionsElbow FractureArmsGlucocorticoids, Saline
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 7 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuangang WuDepartment of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Xiaoxi LuDepartment of Pediatrics, West China University Second Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Yimei MaDepartment of Pediatrics, West China University Second Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Yi ZengDepartment of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Xianchao BaoDepartment of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Huazhang XiongDepartment of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Bin ShenDepartment of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan Province, China. shenbin_1971@163.com.
Sichuan University · CNWest China Second University Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate the efficacy and safety of multiple low-dose dexamethasones in primary total knee arthroplasty (TKA).

methodsOne hundred fifty patients were equally randomized into 3 groups: Group A (n = 50) received 2 doses of normal saline only; Group B (n = 50) received with 1 dose of intravenous dexamethasone and 1 dose of normal saline; Group C (n = 50) received with 2 doses of intravenous dexamethasone. The clinical outcomes and complications were assessed.

resultsThe CRP and IL-6 were significantly lower in Group C and B than Group A at 24, 48, and 72 h postoperatively (P < 0.001 for all). The intensity of postoperative nausea and vomiting (PONV) in Group C was lower than Group A at 24 (P < 0.001, P = 0.002), 48 (P = 0.005, P = 0.041) and 72 h (P = 0.017, P = 0.031) postoperatively and Group B at 24 h (P = 0.027, P = 0.019) postoperatively. Pain were significantly less in Group C than Group A at 24 (P < 0.001), 48 h (P = 0.037) postoperatively and Group B 24 h (P = 0.030) postoperatively. Patients in Group C had better range of motion (ROM) and satisfaction than Group A (P < 0.001, P = 0.002) and B (P = 0.001, P = 0.043). No differences were found in complications.

conclusionsThe administration of 10 mg dexamethasone 1 h before the surgery, and repeated at 6 h postoperatively can significantly reduce the level of postoperative CRP and IL-6 and the incidence of PONV, relieve pain, achieve an additional analgesic effect, and improve the early ROM compared with the other two groups in TKA. LEVEL OF EVIDENCE: Therapeutic Level I.

trial registrationThe Chinese Clinical Trial Registry ( ChiCTR1800017036 ). Registered on July 9, 2018.

Indexed as

Administration, IntravenousAgedAnalgesicsAntiemeticsAnti-Inflammatory AgentsArthroplasty, Replacement, KneeBiomarkersC-Reactive ProteinDexamethasoneDouble-Blind MethodDrug Administration ScheduleFemaleHumansInterleukin-6Length of StayMaleAnalgesicsAntiemeticsAnti-Inflammatory AgentsBiomarkersC-Reactive ProteinDexamethasoneInterleukin-6Clinical outcomesDexamethasonesRandomized controlled studyTotal knee arthroplasty

Identifiers

PMID30501618
PMCPMC6271578
OpenAlexW2902269337

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.