ArticleMolecules (Basel, Switzerland)2018
Bioactivity-Guided Separation of Potential D₂ Dopamine Receptor Antagonists from Aurantii Fructus based on Molecular Docking Combined with High-Speed Counter-Current Chromatography.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 17 citations in OpenAlex.
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- A review on extraction, isolation, characterization of bioactive compounds obtained from agri-food waste and their potential for industrial application.Frontiers in chemistry · 2025Review
- Phytochemical Profile and Antidepressant Effect ofInternational journal of molecular sciences · 2019Article
- New Acylglycosides Flavones from Fuzhuan Brick Tea and Simulation Analysis of Their Bioactive Effects.International journal of molecular sciences · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The typical compounds of Aurantii fructus (AF) reported in previous research were screened for their high antagonistic ability on the D₂ dopamine receptor (D₂R) in silico, and then bioactivity-guided separation was undertaken on the potential D₂R antagonists from AF using high-speed counter-current chromatography (HSCCC). Three flavanones, two polymethoxyflavonoids, and three coumarins were effectively isolated from ethanol extracts of Aurantii fructus (AF) by the use of a two-step HSCCC method, and their chemical structures were identified by mass spectrometry, ¹H-NMR, and
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