Evidence map›Paper›PMID 30501029›Full record

ArticleInternational journal of molecular sciences2018

A Novel Marker of Inflammation: Azurocidin in Patients with ST Segment Elevation Myocardial Infarction.

Emrah Ipek, Mustafa Yolcu, Erkan Yildirim, Konca Altinkaynak, Saime Ozbek Sebin, Kamuran Kalkan, Oktay Gulcu, Emrah Ermis, Mustafa Ozturk

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Neutrophil degranulation and myocardial infarction.Cell communication and signaling : CCS · 2022
    Review
  9. Article
  10. Proteomic Biomarkers of Retinal Inflammation in Diabetic Retinopathy.International journal of molecular sciences · 2019
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Emrah IpekDepartment of Cardiology, Istanbul Cerrahi Hospital, 34365 Istanbul, Turkey. dremrah21@yahoo.com.ORCID 0000-0002-5439-1970
Mustafa YolcuDepartment of Cardiology, Medicana International Hospital, Yeniyuzyil University, 34365 Istanbul, Turkey. yolcudoctor@gmail.com.ORCID 0000-0002-2940-7248
Erkan YildirimDepartment of Cardiology, Biruni University, 34365 Istanbul, Turkey. drerkan23@yahoo.com.
Konca AltinkaynakDepartment of Clinical Biochemistry, University of Health Sciences, Erzurum Training and Research Hospital, 25100 Erzurum, Turkey. kaltinkaynak@hotmail.com.
Saime Ozbek SebinDepartment of Physiology, Ataturk University School of Medicine, 25100 Erzurum, Turkey. laledeniz21@hotmail.com.
Kamuran KalkanDepartment of Cardiology, University of Health Sciences, Erzurum Training and Research Hospital, 25100 Erzurum, Turkey. kalkankamuran@yahoo.com.
Oktay GulcuDepartment of Cardiology, University of Health Sciences, Erzurum Training and Research Hospital, 25100 Erzurum, Turkey. droktaygulcu@gmail.com.
Emrah ErmisDepartment of Cardiology, Biruni University, 34365 Istanbul, Turkey. emr_ermis@hotmail.com.
Mustafa OzturkDepartment of Cardiology, University of Health Sciences, Erzurum Training and Research Hospital, 25100 Erzurum, Turkey. mozturk81@yahoo.com.
Erzurum Regional Training and Research Hospital · TRBiruni University · TRAtatürk University · TRIstanbul Yeni Yüzyıl University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) To investigate the role of azurocidin, an antimicrobial protein, in patients with ST segment elevation myocardial infarction (STEMI). (2) This single-center prospective observational study included patients with STEMI and healthy age- and sex-matched control subjects. Baseline demographic, clinical and biochemical data were compared between the two groups. Azurocidin levels at baseline were determined using an enzyme-linked immunosorbent assay. Multivariate linear regression analysis with enter method was used to test the association between azurocidin and independent variables, such as the thrombolysis in myocardial infarction (TIMI) score, synergy between percutaneous coronary intervention with TAXUS and cardiac surgery score, global registry of acute coronary events score, Killip class, C-reactive protein (CRP), and creatinine kinase-myocardial band (CK-MB). (3) A total of 76 patients with STEMI and 30 healthy control subjects were enrolled in the study. Mean ± SD azurocidin levels were significantly higher in patients compared with healthy controls (18.07 ± 13.99 versus 10.09 ± 5.29 ng/mL, respectively). In a receiver-operating characteristic curve analysis, an azurocidin cut-off level of >11.46 ng/mL had 74% sensitivity and 58% specificity in predicting myocardial infarction. Azurocidin levels had a positive correlation with TIMI score (

Indexed as

AgedAntimicrobial Cationic PeptidesBiomarkersBlood ProteinsCarrier ProteinsEchocardiographyFemaleHumansInflammationLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesROC CurveST Elevation Myocardial InfarctionAntimicrobial Cationic PeptidesAZU1 protein, humanBiomarkersBlood ProteinsCarrier ProteinsazurocidineinflammationST segment elevation myocardial infarction

Identifiers

PMID30501029
PMCPMC6321077
OpenAlexW2902119759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.