Evidence map›Paper›PMID 30501003›Full record

ArticleActa physiologica (Oxford, England)2019

Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation.

Carmen De Miguel, Randee Sedaka, Malgorzata Kasztan, Jeremie M Lever, Michelle Sonnenberger, Andrew Abad, Chunhua Jin, Pamela K Carmines, David M Pollock, Jennifer S Pollock

Open access · greenAbstract read
In one paragraph

Article in Acta physiologica (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Carmen De MiguelSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Randee SedakaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Malgorzata KasztanSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Jeremie M LeverDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Michelle SonnenbergerSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Andrew AbadSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Chunhua JinSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Pamela K CarminesDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
David M PollockSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-0233-2362
Jennifer S PollockSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-1956-0449
University of Alabama at Birmingham · USUniversity of Nebraska Medical Center · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI POLLOCK, JENNIFER S · 2002 to 2018
$31.1M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
Renal endothelin receptor-specific function in angiotensin ll-dependent hypertensP01HL095499 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SULLIVAN, JENNIFER C · 2010 to 2014
$11.1M
The Role of Endothelin-1 in Sickle Cell DiseaseU01HL117684 · NHLBI · AUGUSTA UNIVERSITY · PI KUTLAR, ABDULLAH, MEILER, STEFFEN · 2013 to 2017
$8.1M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
Role of endothelin in hypertension-mediated inflammation and end-organ damageK01HL145324 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE MIGUEL, CARMEN · 2019 to 2023
$763k
Myeloid Expression of Heme Oxygenase-1 in the AKI to CKD TransitionF31DK115169 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVER, JEREMIE MATTHEW PEABODY · 2017 to 2020
$160k
Novel Mechanisms of Nitric Oxide Activation in the KidneyF31DK111067 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SEDAKA, RANDEE · 2016 to 2018
$103k
American Heart Association 15SFRN2390002American Society of NephrologyNHLBI NIH HHS K01 HL145324NHLBI NIH HHS P01 HL069999NHLBI NIH HHS P01 HL095499NHLBI NIH HHS P01 HL136267NHLBI NIH HHS U01 HL117684NIDDK NIH HHS F31 DK111067NIDDK NIH HHS F31 DK115169NIDDK NIH HHS P30 DK079626NIDDK NIH HHS T32 DK007545NIGMS NIH HHS T32 GM008361NIH HHS P01 HL136267
6 · The paper itself

Abstract

aimChronic high salt intake exaggerates renal injury and inflammation, especially with the loss of functional ET

methodsET

resultsIn ET

conclusionsTUDCA protects against the development of glomerular and proximal tubular damage, decreases renal cell death and inflammation in the renal cortex in rats with ET

Indexed as

AnimalsAnimals, Genetically ModifiedGene DeletionInflammationKidney DiseasesMaleRandom AllocationRatsReceptor, Endothelin BSodium Chloride, DietaryTaurochenodeoxycholic Acidednrb protein, ratReceptor, Endothelin BSodium Chloride, DietaryTaurochenodeoxycholic AcidursodoxicoltaurineCD4+ T cellscell deathETB receptorshigh salt dietrenal injury

Identifiers

PMID30501003
PMCPMC6462246
OpenAlexW2902497454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.