Evidence map›Paper›PMID 30500981›Full record

Trial reportCancer2019

Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise in survivors of breast cancer.

Christina M Dieli-Conwright, Frank C Sweeney, Kerry S Courneya, Debu Tripathy, Nathalie Sami, Kyuwan Lee, Thomas A Buchanan, Darcy Spicer, Leslie Bernstein, Joanne E Mortimer and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  8. Trial
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  11. Article
  12. Article
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  15. Factors Impacting Management of Breast Cancer-Related Lymphedema (BCRL) in Hispanic/Latina Breast Cancer Survivors: A Literature Review.Hispanic health care international : the official journal of the National Association of Hispanic Nurses · 2021
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina M Dieli-ConwrightDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
Frank C SweeneyDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
Debu TripathyDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Nathalie SamiDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
Kyuwan LeeDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California.
Thomas A BuchananDivision of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California.
Darcy SpicerDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Leslie BernsteinDivision of Biomarkers of Early Detection and Prevention, Beckman Research Institute, City of Hope, Duarte, California.
Joanne E MortimerDivision of Medical Oncology and Experimental Therapeutics, City of Hope, Duarte, California.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0001-5241-932X

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise InterventionK07CA160718 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DIELI-CONWRIGHT, CHRISTINA · 2011 to 2015
$629k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS K07 CA160718
6 · The paper itself

Abstract

backgroundMetabolic syndrome (MSY) is associated with an increased risk of cardiovascular disease, type 2 diabetes, and recurrence in breast cancer survivors (BCS). MSY is 1.5 times more common in Hispanic women compared with non-Hispanic women. Although exercise mitigates MSY in BCS, to the best of the authors' knowledge, few studies to date have focused on minorities. This secondary analysis examined ethnicity as a moderator of the effects of a 16-week aerobic and resistance exercise intervention on MSY, sarcopenic obesity, and serum biomarkers in BCS.

methodsA total of 100 eligible BCS were randomized to exercise (50 BCS) or usual care (50 BCS). The exercise intervention promoted moderate to vigorous aerobic and resistance exercise 3 times a week for 16 weeks. MSY z scores, sarcopenic obesity, and serum biomarkers were measured at baseline, after the intervention, and at the 28-week follow-up (exercise group only). Linear mixed models adjusted for baseline values of the outcome, age, disease stage, adjuvant treatment, and recent physical activity were used to evaluate effect modification by ethnicity.

resultsThe study sample was 57% Hispanic BCS (HBCS) and 43% non-Hispanic BCS (NHBCS). HBCS were younger, of greater adiposity, and had been diagnosed with more advanced cancers compared with NHBCS (P<.001). Ethnicity was found to moderate the mean differences in exercise training on triglycerides (-36.4 mg/dL; 95% confidence interval [95% CI],-64.1 to -18.8 mg/dL), glucose (-8.6 mg/dL; 95% CI, -19.1 to -3.0 mg/dL), and C-reactive protein (-3.3 mg/L; 95% CI, -7.3 to -0.9 mg/L).

conclusionsHBCS appear to have poorer metabolic profiles and therefore may derive relatively larger metabolic changes from exercise compared with NHBCS. Clinical exercise interventions may attenuate existing health disparities across diverse groups of BCS.

Indexed as

AdultAgedBiomarkersBreast NeoplasmsCancer SurvivorsExerciseFemaleHispanic or LatinoHumansMiddle AgedObesityResistance TrainingSarcopeniaTreatment OutcomeBiomarkersexerciseHispanic breast cancer survivorsmetabolic syndromeobesity

Identifiers

PMID30500981
PMCPMC7164690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.