Observational studyNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2019
Accelerated podocyte detachment early after kidney transplantation is related to long-term allograft loss of function.
Observational study in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure.JCI insight · 2025Article
- Podocyturia an emerging biomarker for kidney injury.BMC nephrology · 2025Review
- Advancing the application of the analytical renal pathology system in allograft IgA nephropathy patients.Renal failure · 2024Article
- Urinary podocyte markers of disease activity, therapeutic efficacy, and long-term outcomes in acute and chronic kidney diseases.Clinical and experimental nephrology · 2024Review
- Recognition of intraglomerular histological features with deep learning in protocol transplant biopsies and their association with kidney function and prognosis.Clinical kidney journal · 2024Article
- Re-Evaluating the Transplant Glomerulopathy Lesion-Beyond Donor-Specific Antibodies.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Beyond UPR: cell-specific roles of ER stress sensor IRE1α in kidney ischemic injury and transplant rejection.Kidney international · 2023Review
- Article
- The Michigan O'Brien Kidney Research Center: transforming translational kidney research through systems biology.American journal of physiology. Renal physiology · 2022Review
- Hypertrophy and glomerular cell adaptation through crosstalk leads to glomerular injury after kidney transplantation.Kidney international · 2022Article
- Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants.Kidney international · 2022Article
- Article
- The cellular landscape of the normal kidney allograft: Main players balancing the alloimmune response.Frontiers in transplantation · 2022Article
- Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan.Clinical transplantation · 2021Article
- Critical timing of ACEi initiation prevents compensatory glomerular hypertrophy in the remaining single kidney.Scientific reports · 2021Article
- Urinary mRNA Expression of Glomerular Podocyte Markers in Glomerular Disease and Renal Transplant.Diagnostics (Basel, Switzerland) · 2021Article
- Chronic transplant glomerulopathy: New insights into pathogenesis.Clinical transplantation · 2021Review
- N-glycosylated IgG in patients with kidney transplants increases calcium/calmodulin kinase IV in podocytes and causes injury.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Urinary podocyte mRNAs precede microalbuminuria as a progression risk marker in human type 2 diabetic nephropathy.Scientific reports · 2020Article
- Podocyte stress and detachment measured in urine are related to mean arterial pressure in healthy humans.Kidney international · 2020Observational
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundKidney allograft half-life has not improved despite excellent short-term survival. Recent long-term surveillance biopsy studies identify accumulating glomerulosclerosis (GS) to be associated with late allograft loss. While podocyte depletion is well known to drive proteinuria and GS in animal models and human glomerular diseases, its role in renal allograft loss of function is generally not recognized.
methodsTo address these questions, we collected urine from 125 kidney allograft recipients in the first posttransplant year for urine pellet messenger RNA (mRNA) and protein analysis, with a median follow up of 4.5 years.
resultsUsing multivariable linear models adjusted for proteinuria, transplant, recipient and donor factors, we observed that the average urine pellet podocin mRNA normalized to urine creatinine (UPodCR) in the first posttransplant year was significantly associated with an estimated glomerular filtration rate (eGFR) decline (P = 0.001). The relationship between UPodCR and eGFR decline persisted even among recipients who were nonproteinuric and who had no recurrent or de novo glomerular disease identified on 1-year protocol biopsy. Finally, we identified recipient, donor and recipient:donor body surface area mismatch ratio to be independently associated with UPodCR early after transplantation. A larger donor was protective, while a larger recipient and increased recipient:donor size mismatch ratio were associated with increased UPodCR.
conclusionsThese findings support the concept that in kidney allografts, accelerated podocyte loss precedes proteinuria and is associated with inferior long-term allograft outcomes as measured by eGFR decline and may be initiated by recipient:donor size mismatch. Modulating factors driving early podocyte detachment after kidney transplantation may help improve long-term outcomes.
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