Evidence map›Paper›PMID 30500928›Full record

ReviewThe Journal of nutrition2018

Biomarkers of Nutrition for Development (BOND): Vitamin B-12 Review.

Lindsay H Allen, Joshua W Miller, Lisette de Groot, Irwin H Rosenberg, A David Smith, Helga Refsum, Daniel J Raiten

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07296393 (The Association Between Umbilical Cord Blood Vitamin A Levels and Adverse Outcomes in Extremely Preterm Infants), which is not on this map. Cited by 171 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07296393 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Association Between Umbilical Cord Blood Vitamin A Levels and Adverse Outcomes in Extremely Preterm Infants: A Single-Center Prospective Cohort Study

TypeobservationalSponsorThe First Hospital of Jilin UniversityRan2025 to 2027Enrolled155ConditionsExtremely Premature Infant
3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Assessment of vitamin A, vitamin BEuropean journal of nutrition · 2025
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  15. A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lindsay H AllenUSDA, Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, CA.
Joshua W MillerDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ.
Lisette de GrootDivision of Human Nutrition, Wageningen University, Wageningen, Netherlands.
Irwin H RosenbergFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
A David SmithDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Helga RefsumDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Daniel J RaitenEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report on vitamin B-12 (B12) is part of the Biomarkers of Nutrition for Development (BOND) Project, which provides state-of-the art information and advice on the selection, use, and interpretation of biomarkers of nutrient exposure, status, and function. As with the other 5 reports in this series, which focused on iodine, folate, zinc, iron, and vitamin A, this B12 report was developed with the assistance of an expert panel (BOND B12 EP) and other experts who provided information during a consultation. The experts reviewed the existing literature in depth in order to consolidate existing relevant information on the biology of B12, including known and possible effects of insufficiency, and available and potential biomarkers of status. Unlike the situation for the other 5 nutrients reviewed during the BOND project, there has been relatively little previous attention paid to B12 status and its biomarkers, so this report is a landmark in terms of the consolidation and interpretation of the available information on B12 nutrition. Historically, most focus has been on diagnosis and treatment of clinical symptoms of B12 deficiency, which result primarily from pernicious anemia or strict vegetarianism. More recently, we have become aware of the high prevalence of B12 insufficiency in populations consuming low amounts of animal-source foods, which can be detected with ≥1 serum biomarker but presents the new challenge of identifying functional consequences that may require public health interventions.

Indexed as

Nutritional StatusBiomarkersHumansVitamin B 12Vitamin B 12 DeficiencyVitamin B ComplexBiomarkersVitamin B 12Vitamin B Complex

Identifiers

PMID30500928
PMCPMC6297555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.