Evidence map›Paper›PMID 30500864›Full record

ArticlePloS one2018

Enhancer-driven alternative promoters of imprinted genes.

Joomyeong Kim, Bambarendage P U Perera, Subash Ghimire

Abstract read
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In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joomyeong KimDepartment of Biological Sciences, Louisiana State University, Baton Rouge, United States of America.ORCID 0000-0001-6577-5526
Bambarendage P U PereraDepartment of Biological Sciences, Louisiana State University, Baton Rouge, United States of America.
Subash GhimireDepartment of Biological Sciences, Louisiana State University, Baton Rouge, United States of America.ORCID 0000-0001-9544-4410

Funding

Imprinting studies of a paternally expressed Usp29 geneR01GM066225 · NIGMS · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI KIM, JOOMYEONG · 2004 to 2013
$2.6M
Aebp2 as an epigenetic regulator for neural crest cellR01GM097074 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KIM, JOOMYEONG · 2013 to 2016
$1.1M
NIGMS NIH HHS R01 GM066225NIGMS NIH HHS R01 GM097074
6 · The paper itself

Abstract

In the current study, we characterized the expression and histone modification profiles of the alternative promoters found within imprinted Igf2r, Mest, Zac1, Peg3, Snrpn and non-imprinted Myc loci. In terms of expression pattern, the alternative promoters are highly tissue-specific, which is in a stark contrast to the ubiquitous expression of the corresponding main promoters. The alternative promoters are associated with the histone modification mark H3K4me1, but not with H3K4me3, which is frequently associated with the main promoters. Phylogenetic analyses also indicated that the majority of the alternative promoters are unique to the mammalian lineage, further suggesting the recent formation of these promoters during mammalian evolution. Overall, this study suggests that the alternative promoters of imprinted loci may have been derived from enhancers in recent evolutionary times and co-evolved with the genomic imprinting mechanism.

Indexed as

Genomic ImprintingHistone CodePromoter Regions, GeneticAnimalsCell Cycle ProteinsEnhancer Elements, GeneticExonsFemaleGenes, Tumor SuppressorGenetic LociKruppel-Like Transcription FactorsMaleMice, Inbred C57BLPhylogenyProteinsProto-Oncogene Proteins c-mycCell Cycle ProteinsKruppel-Like Transcription Factorsmesoderm specific transcript proteinPeg3 protein, mousePlagl1 protein, mouseProteinsProto-Oncogene Proteins c-mycReceptor, IGF Type 2snRNP Core ProteinsTranscription Factors

Identifiers

PMID30500864
PMCPMC6267961

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.