Evidence map›Paper›PMID 30500399›Full record

ArticleBrain research2019

miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice.

Lei Wang, Michael Chopp, XueRong Lu, Alexandra Szalad, LongFei Jia, Xian Shuang Liu, Kuan-Han Wu, Mei Lu, Zheng Gang Zhang

Abstract read
In one paragraph

Article in Brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Genetic and Epigenomic Modifiers of Diabetic Neuropathy.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lei WangDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States. Electronic address: leiwang@neuro.hfh.edu.
Michael ChoppDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States; Department of Physics, Oakland University, Rochester, MI 48309, United States.
XueRong LuDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
Alexandra SzaladDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
LongFei JiaDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
Xian Shuang LiuDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
Kuan-Han WuDepartment of Biostatistics and Research Epidemiology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
Mei LuDepartment of Biostatistics and Research Epidemiology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
Zheng Gang ZhangDepartment of Neurology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, United States.
Henry Ford Hospital · USOakland University · US

Funding

Translational study of miR-146a gene therapy for diabetic peripheral neuropathyR01DK102861 · NIDDK · HENRY FORD HEALTH SYSTEM · PI LIU, XIANSHUANG · 2015 to 2018
$1.3M
Thymosin Beta4 Promotes the Recovery of Peripheral neuropathy in Type II DiabeticR01DK097519 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WANG, LEI · 2013 to 2016
$1.3M
PDE5 is a Therapeutic Target for Peripheral Neuropathy in Diabetic MiceR01NS075084 · NINDS · HENRY FORD HEALTH SYSTEM · PI WANG, LEI · 2012 to 2015
$1.3M
NIDDK NIH HHS R01 DK097519NIDDK NIH HHS R01 DK102861NINDS NIH HHS R01 NS075084
6 · The paper itself

Abstract

Diabetes induces neurovascular dysfunction leading to peripheral neuropathy. MicroRNAs (miRNAs) affect many biological processes and the development of diabetic peripheral neuropathy. In the present study, we investigated whether thymosin-β4 (Tβ4) ameliorates diabetic peripheral neuropathy and whether miR-146a mediates the effect of Tβ4 on improved neurovascular function. Male Type II diabetic BKS. Cg-m+/+Lepr

Indexed as

AnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diabetic NeuropathiesDisease Models, AnimalEndothelial CellsGanglia, SpinalInterleukin-1 Receptor-Associated KinasesMaleMiceMice, TransgenicMicroRNAsNeuronal OutgrowthNF-kappa BSciatic NerveSignal TransductionInterleukin-1 Receptor-Associated KinasesIrak1 protein, mouseMicroRNAsNF-kappa BThymosinThymosin beta(4)TNF Receptor-Associated Factor 6TRAF6 protein, mouseDiabetesMicemiR-146aPeripheral neuropathyThymosin β4

Identifiers

PMID30500399
PMCPMC6372311
OpenAlexW2902374089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.