ArticleOsteoarthritis and cartilage2019
The association of frontal plane alignment to MRI-defined worsening of patellofemoral osteoarthritis: the MOST study.
Article in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Perspective: One and one make three - leveraging the synergy of imaging and biomechanics in osteoarthritis research and care.Osteoarthritis imaging · 2026Article
- Measures of Patellofemoral Morphology Predict the Risk of Local Cartilage Damage Progression: A Yale/MOST Collaborative Study.The American journal of sports medicine · 2025Article
- The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study.Osteoarthritis and cartilage · 2025Article
- Methods of measuring radiographic patellofemoral joint alignment and morphology: A scoping review.Osteoarthritis imaging · 2025Article
- Classification approaches used to grade radiographic patellofemoral osteoarthritis: A scoping review.Osteoarthritis imaging · 2025Article
- Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study.Osteoarthritis and cartilage · 2024Article
- Patellar Dislocation in Adolescent Patients: Influence on Cartilage Properties Based on T1ρ Relaxation Times.The American journal of sports medicine · 2023Article
- Excessive femoral torsion is not associated with patellofemoral pain or instability if TKA is functionally aligned and the patella denervated.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- The winking sign is an indicator for increased femorotibial rotation in patients with recurrent patellar instability.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Increased femoral antetorsion correlates with higher degrees of lateral retropatellar cartilage degeneration, further accentuated in genu valgum.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Setting up distinctive outcome measures for each osteoarthritis phenotype.Therapeutic advances in musculoskeletal disease · 2020Review
- Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
Abstract
objectiveTo determine the sex-specific relation of frontal plane alignment (FPA) to magnetic resonance imaging (MRI)-defined features of patellofemoral osteoarthritis, and also to tibiofemoral osteoarthritis and knee pain.
methodThe Multicenter Osteoarthritis Study is cohort study comprised of individuals with or at risk of knee osteoarthritis. We determined the sex-specific dose-response relation of baseline FPA to MRI-defined patellofemoral and tibiofemoral structural worsening, and incident knee pain, over 7 years.
resultsIn women only, greater varus alignment was associated with medial patellofemoral osteophytes (risk ratio [RR] 1.7 [95% CI 1.2, 2.6]) and valgus with lateral patellofemoral osteophytes (RR 1.9 [1.0, 3.6]). In men, greater varus increased risk for medial tibiofemoral cartilage worsening (RR 1.7 [1.1, 2.6]), and valgus for lateral tibiofemoral cartilage worsening (RR 1.8 [1.6, 2.2]). In women, findings were similar for tibiofemoral cartilage, but varus also increased risk for medial bone marrow lesions [BMLs] (RR 2.2 [1.6, 3.1]) and medial osteophytes (RR 1.8 [1.3, 2.5]), and valgus for lateral BMLs (RR 3.3 [2.2, 4.5]) and osteophytes (RR 2.0 [1.2, 3.2]). Varus increased risk of incident pain in men (RR 1.7 [1.4, 2.2]) and women (RR 1.3 [1.0, 1.6]), valgus did so in men only (RR 1.5 [1.1, 1.9]).
conclusionFPA was associated with patellofemoral osteophyte worsening in women, though overall was more strongly associated with tibiofemoral than patellofemoral osteoarthritis feature worsening. FPA in women was more consistently associated with structural worsening, yet men had higher associations with incident pain.
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