Evidence map›Paper›PMID 30500207›Full record

ArticleACS chemical biology2019

Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry.

Philip K Yuen, Sydnee A Green, Jonathan Ashby, Kori T Lay, Abhishek Santra, Xi Chen, Martin P Horvath, Sheila S David

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Philip K YuenDepartment of Chemistry , University of California , Davis , California 95616 , United States.
Sydnee A GreenDepartment of Chemistry , University of California , Davis , California 95616 , United States.
Jonathan AshbyDepartment of Chemistry , University of California , Davis , California 95616 , United States.
Kori T LayDepartment of Chemistry , University of California , Davis , California 95616 , United States.
Abhishek SantraDepartment of Chemistry , University of California , Davis , California 95616 , United States.
Xi ChenDepartment of Chemistry , University of California , Davis , California 95616 , United States.ORCID 0000-0002-3160-614X
Martin P HorvathSchool of Biological Sciences , University of Utah , Salt Lake City , Utah 84112 , United States.
Sheila S DavidDepartment of Chemistry , University of California , Davis , California 95616 , United States.ORCID 0000-0001-5873-7935
University of California, Davis · USUniversity of Utah · US

Funding

Training Program in Oncogenic Signals and Chromosome BiologyT32CA108459 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEYER, WOLF-DIETRICH · 2006 to 2020
$3.6M
Supplement: Exploring the biology of O-acetyl sialic acids using stable synthetic mimicsR01AI130684 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI, VARKI, AJIT P · 2017 to 2020
$2.3M
Training in Cancer PharmacologyT32CA108455 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI LIU, LEROY F · 2005 to 2009
$1.3M
UC Davis Training Program in Chemical BiologyT32GM113770 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEAL, PETER A. · 2015 to 2019
$742k
NCI NIH HHS T32 CA108455NCI NIH HHS T32 CA108459NIAID NIH HHS R01 AI130684NIGMS NIH HHS T32 GM113770
6 · The paper itself

Abstract

DNA glycosylases of the base excision repair (BER) pathway are front-line defenders in removing compromising modifications of the DNA nucleobases. Aberrantly modified nucleobases mediate genomic mutations and inhibit DNA replication leading to adverse health consequences such as cancer, neurological diseases, and aging. In an effort to develop high-affinity transition state (TS) analogues as chemical biology probes for DNA glycosylases, oligonucleotides containing a propargyl-modified pyrrolidine TS mimic nucleotide were synthesized. A small library of TS mimic-containing oligonucleotides was generated using a structurally diverse set of five azides via copper(I)-catalyzed azide-alkyne cycloaddition "click" chemistry. The relative affinity ( K

Indexed as

Click ChemistryDNA RepairMolecular MimicryDNA GlycosylasesEscherichia coliEscherichia coli ProteinsHumansLigandsOligonucleotidesProtein BindingDNA GlycosylasesEscherichia coli ProteinsLigandsOligonucleotides

Identifiers

PMID30500207
PMCPMC6825804
OpenAlexW2903262328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.