Evidence map›Paper›PMID 30499775›Full record

ArticleeLife2018

A novel enhancer near the

Abbey C Thompson, Terence D Capellini, Catherine A Guenther, Yingguang Frank Chan, Carlos R Infante, Douglas B Menke, David M Kingsley

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 54 citations in OpenAlex.

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  13. Distinct regulatory states control the elongation of individual skeletal rods in the sea urchin embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  14. Speciation and adaptation research meets genome editing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  15. An enhancer ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Abbey C ThompsonDepartment of Developmental Biology, Stanford University School of Medicine, California, United States.
Terence D CapelliniDepartment of Developmental Biology, Stanford University School of Medicine, California, United States.ORCID 0000-0003-3842-8478
Catherine A GuentherDepartment of Developmental Biology, Stanford University School of Medicine, California, United States.
Yingguang Frank ChanDepartment of Developmental Biology, Stanford University School of Medicine, California, United States.ORCID 0000-0001-6292-9681
Carlos R InfanteDepartment of Genetics, University of Georgia, Georgia, United States.
Douglas B MenkeDepartment of Genetics, University of Georgia, Georgia, United States.ORCID 0000-0002-7109-1451
David M KingsleyDepartment of Developmental Biology, Stanford University School of Medicine, California, United States.ORCID 0000-0002-6401-6461
Stanford University · USHoward Hughes Medical Institute · USUniversity of Georgia · US

Funding

INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
Genomic Basis of Vertebrate DiversityP50HG002568 · NHGRI · STANFORD UNIVERSITY · PI KINGSLEY, DAVID M · 2002 to 2011
$29.2M
Developmental context and the control of appendage cis-regulatory networksR01HD081034 · NICHD · UNIVERSITY OF GEORGIA · PI MENKE, DOUGLAS BAY · 2014 to 2018
$1.5M
Role of PITX1 regulatory mutations in morphological variation and human lower limb abnormalitiesF31AR068870 · NIAMS · STANFORD UNIVERSITY · PI THOMPSON, ABBEY CAROLYN · 2015 to 2017
$78k
Howard Hughes Medical InstituteNational Institute of Child Health and Human Development HD081034NHGRI NIH HHS Center of Excellence in Genomic Science - 3P50 HG002568NHGRI NIH HHS P50 HG002568NHGRI NIH HHS Stanford Genome Training Program - 5T32HG0004NHGRI NIH HHS T32 HG000044NIAMS NIH HHS F31 AR068870NIAMS NIH HHS Ruth L. Kirschstein National Research Service Award - 1F31AR068870NICHD NIH HHS R01 HD081034
6 · The paper itself

Abstract

Vertebrate pelvic reduction is a classic example of repeated evolution. Recurrent loss of pelvic appendages in sticklebacks has previously been linked to natural mutations in a pelvic enhancer that maps upstream of

Indexed as

Biological EvolutionEnhancer Elements, GeneticAnimalsBase SequenceChromosomes, Artificial, BacterialConserved SequenceFishesGene Expression Regulation, DevelopmentalGenetic LociGenomeHindlimbLizardsMicePaired Box Transcription FactorsPelvisSequence Deletionhomeobox protein PITX1Paired Box Transcription Factorsdevelopmental biologyenhancerevolutionevolutionary biologyhindlimb developmentmousepelvispitx1stickleback

Identifiers

PMID30499775
PMCPMC6269122
OpenAlexW2902937254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.