Evidence map›Paper›PMID 30499763›Full record

ArticleInternational journal of radiation biology2019

MRI evaluation of the effects of whole brain radiotherapy on breast cancer brain metastasis.

William Crowe, Lulu Wang, Zhongwei Zhang, Jasmina Varagic, J Daniel Bourland, Michael D Chan, Amyn A Habib, Dawen Zhao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

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  14. The blood-tumour barrier in cancer biology and therapy.Nature reviews. Clinical oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

William Crowea Department of Biomedical Engineering , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Lulu Wanga Department of Biomedical Engineering , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Zhongwei Zhanga Department of Biomedical Engineering , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Jasmina Varagicb Department of Surgery , Wake Forest School of Medicine , Winston-Salem , NC , USA.
J Daniel Bourlanda Department of Biomedical Engineering , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Michael D Chanc Department of Radiation Oncology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Amyn A Habibd Department of Neurology and Neurotherapeutics , University of Texas Southwestern Medical Center and VA North Texas Medical Center , Dallas , TX , USA.
Dawen Zhaoa Department of Biomedical Engineering , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Wake Forest University · USThe University of Texas Southwestern Medical Center · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Convertible MRI contrast signaling delivery and release of anti-glioma nano-drugR01CA194578 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHAO, DAWEN · 2015 to 2019
$1.8M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA194578
6 · The paper itself

Abstract

purposeTo assess early changes in brain metastasis in response to whole brain radiotherapy (WBRT) by longitudinal Magnetic Resonance Imaging (MRI). MATERIALS AND

methodsUsing a 7T system, MRI examinations of brain metastases in a breast cancer MDA-MD231-Br mouse model were conducted before and 24 hours after 3 daily fractionations of 4 Gy WBRT. Besides anatomic MRI, diffusion-weighted (DW) MRI and dynamic contrast-enhanced (DCE) MRI were applied to study cytotoxic effect and blood-tumor-barrier (BTB) permeability change, respectively.

resultsBefore treatment, high-resolution T2-weighted images revealed hyperintense multifocal lesions, many of which (∼50%) were not enhanced on T1-weighted contrast images, indicating intact BTB in the brain metastases. While no difference in the number of new lesions was observed, WBRT-treated tumors were significantly smaller than sham controls (p < .05). DW MRI detected significant increase in apparent diffusion coefficient (ADC) in WBRT tumors (p < .05), which correlated with elevated caspase 3 staining of apoptotic cells. Many lesions remained non-enhanced post WBRT. However, quantitative DCE MRI analysis showed significantly higher permeability parameter, K

conclusionsMRI allowed non-invasive assessments of WBRT induced changes in BTB permeability, which may provide useful information for potential combination treatment.

Indexed as

Magnetic Resonance ImagingAnimalsBrain NeoplasmsBreast NeoplasmsCell Line, TumorFemaleHumansMiceMice, Inbred BALB CTreatment OutcomeXenograft Model Antitumor Assaysblood-tumor-barrier (BTB)Brain metastasisdiffusion-weighted (DW) MRIdynamic contrast-enhanced (DCE) MRIvolume transfer coefficient Ktranswhole brain radiotherapy (WBRT)

Identifiers

PMID30499763
PMCPMC6748640
OpenAlexW2902062766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.