Evidence map›Paper›PMID 30499689›Full record

ReviewBiomarkers in medicine2018

Cardiac MRI biomarkers for Duchenne muscular dystrophy.

Patrick Magrath, Nyasha Maforo, Pierangelo Renella, Stanley F Nelson, Nancy Halnon, Daniel B Ennis

Open access · hybridAbstract readReview
In one paragraph

Review in Biomarkers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Localized strain characterization of cardiomyopathy in Duchenne muscular dystrophy using novel 4D kinematic analysis of cine cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  13. Article
  14. The Many Faces of Arrhythmogenic Cardiomyopathy: An Overview.The application of clinical genetics · 2023
    Review
  15. Article
  16. Myocardial strain imaging in Duchenne muscular dystrophy.Frontiers in cardiovascular medicine · 2022
    Review
  17. Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Patrick MagrathDepartment of Radiological Sciences, University of California, Los Angeles, CA 90024, USA.
Nyasha MaforoDepartment of Radiological Sciences, University of California, Los Angeles, CA 90024, USA.
Pierangelo RenellaDepartment of Radiological Sciences, University of California, Los Angeles, CA 90024, USA.
Stanley F NelsonCenter for Duchenne Muscular Dystrophy, Department of Human Genetics, University of California, Los Angeles, CA 90095, USA.
Nancy HalnonDepartment of Radiological Sciences, University of California, Los Angeles, CA 90024, USA.
Daniel B EnnisDepartment of Radiological Sciences, University of California, Los Angeles, CA 90024, USA.
University of California, Los Angeles · USChildren's Hospital of Orange County · USMuscular Dystrophy Association · US

Funding

Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMDR01HL131975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENNIS, DANIEL B · 2016 to 2019
$2.5M
NHLBI NIH HHS R01 HL131975
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a fatal inherited genetic disorder that results in progressive muscle weakness and ultimately loss of ambulation, respiratory failure and heart failure. Cardiac MRI (MRI) plays an increasingly important role in the diagnosis and clinical care of boys with DMD and associated cardiomyopathies. Conventional cardiac MRI biomarkers permit measurements of global cardiac function and presence of fibrosis, but changes in these measures are late manifestations. Emerging MRI biomarkers of myocardial function and structure include the estimation of rotational mechanics and regional strain using MRI tagging; T1-mapping; and T2-mapping, a marker of inflammation, edema and fat. These emerging biomarkers provide earlier insights into cardiac involvement in DMD, improving patient care and aiding the evaluation of emerging therapies.

Indexed as

Magnetic Resonance ImagingBiomarkersCardiomyopathiesContrast MediaGadoliniumHumansMuscle, SkeletalMuscular Dystrophy, DuchenneMyocardiumBiomarkersContrast MediaGadoliniumbiomarkersDuchenne muscular dystrophyMRI

Identifiers

PMID30499689
PMCPMC6462870
OpenAlexW2903478736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.