ArticleJournal of veterinary internal medicine2019
Prevalence of Clostridium perfringens netE and netF toxin genes in the feces of dogs with acute hemorrhagic diarrhea syndrome.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Presentations of idiopathic hemorrhagic diarrhea syndrome in dogs in relation to meteorological factors.Journal of veterinary internal medicine · 2026Article
- Antimicrobial resistance and genetic characterization ofOne health (Amsterdam, Netherlands) · 2026Article
- Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor.Nature communications · 2026Article
- Feline enteropathogens and molecular diagnostics: benefits, limitations and clinical applications.Journal of feline medicine and surgery · 2025Review
- Prevalence and toxin gene profiles ofJournal of veterinary science · 2025Article
- Clinical Guidelines for Fecal Microbiota Transplantation in Companion Animals.Advances in small animal care · 2024Article
- Genome sequences ofMicrobiology resource announcements · 2024Article
- The Effect of Metronidazole versus a Synbiotic on Clinical Course and Core Intestinal Microbiota in Dogs with Acute Diarrhea.Veterinary sciences · 2024Article
- Evaluation of Intestinal Barrier Dysfunction with Serum Iohexol Concentration in Dogs with Acute Hemorrhagic Diarrhea Syndrome.Animals : an open access journal from MDPI · 2024Article
- Article
- Defining a metagenomic threshold for detecting low abundances ofFrontiers in cellular and infection microbiology · 2024Article
- Bacterial attachment and junctional transport function in induced apical-out polarized and differentiated canine intestinal organoids.Frontiers in veterinary science · 2024Article
- Clinical response in dogs with acute hemorrhagic diarrhea syndrome following randomized probiotic treatment or fecal microbiota transplant.Frontiers in veterinary science · 2023Article
- Necrotic Enteritis in Broiler Chickens: A Review on the Pathogen, Pathogenesis, and Prevention.Microorganisms · 2022Review
- Effects of Canine-Obtained Lactic-Acid Bacteria on the Fecal Microbiota and Inflammatory Markers in Dogs Receiving Non-Steroidal Anti-Inflammatory Treatment.Animals : an open access journal from MDPI · 2022Article
- Efficacy of feeding a diet containing a high concentration of mixed fiber sources for management of acute large bowel diarrhea in dogs in shelters.Journal of veterinary internal medicine · 2022Article
- Intra-species diversity ofFrontiers in microbiology · 2022Article
- Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea.Journal of veterinary internal medicine · 2022Article
- Pathogenicity and virulence ofVirulence · 2021Article
- An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points toAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, novel pore-forming toxin genes designated netE and netF were identified in a Clostridium perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea.
objectivesPore-forming toxins could play an important role in the disease pattern of acute hemorrhagic diarrhea syndrome (AHDS) in dogs. Thus, we aimed to determine the prevalence of C. perfringens genes encoding for netE and netF in the feces of dogs with AHDS and to evaluate any association between selected clinical variables and the presence of these toxin genes. ANIMALS: In total, 174 dogs were included in the study.
methodsFecal samples of all dogs were tested by real-time polymerase chain reaction for netE and netF genes. Time to recovery, hospitalization time, and selected laboratory variables were compared between dogs with AHDS that were positive or negative for the toxin genes.
resultsA significant difference was found among the 3 groups in the prevalence of the pore-forming toxin genes netE and netF: dogs with AHDS: 26 of 54 (48.1%); dogs with canine parvovirus (CPV) infection: 0 of 54 (0%); and healthy dogs: 8 of 66 (12.1%; P < .001). In dogs with AHDS, no significant difference was detected in any variables evaluated between netE-positive and netF-positive and netE-negative and netF-negative dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: The prevalence of C. perfringens encoding for netE and netF is significantly higher in dogs with AHDS compared to control dogs. Further studies are warranted to evaluate whether these toxins are an inciting cause for AHDS in dogs.
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