ArticleMolecular plant pathology2019
The Ralstonia solanacearum effector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Pathogen effector tactics to suppress plant endomembrane system.Frontiers in plant science · 2026Review
- Molecular Dialog ofInternational journal of molecular sciences · 2025Review
- The disordered effector RipAO of Ralstonia solanacearum destabilizes microtubule networks in Nicotiana benthamiana cells.Molecules and cells · 2025Article
- Logistics of defense: The contribution of endomembranes to plant innate immunity.The Journal of cell biology · 2024Review
- TheMolecules and cells · 2023Article
- Multitask Approach to Localize Rhizobial Type Three Secretion System Effector Proteins Inside Eukaryotic Cells.Plants (Basel, Switzerland) · 2023Article
- From prediction to function: Current practices and challenges towards the functional characterization of type III effectors.Frontiers in microbiology · 2023Review
- Ubiquitin E3 ligase activity ofFrontiers in microbiology · 2023Article
- Biocontrol of bacterial wilt disease in tomato usingFrontiers in microbiology · 2023Article
- Complete Genome Sequence Analysis ofFrontiers in microbiology · 2022Article
- Comprehensive genome sequence analysis of the devastating tobacco bacterial phytopathogenFrontiers in genetics · 2022Article
- What the Wild Things Do: Mechanisms of Plant Host Manipulation by Bacterial Type III-Secreted Effector Proteins.Microorganisms · 2021Review
- Microbial Musings - December 2020.Microbiology (Reading, England) · 2020Article
- The large, diverse, and robust arsenal of Ralstonia solanacearum type III effectors and their in planta functions.Molecular plant pathology · 2020Review
- Brassinosteroids Antagonize Jasmonate-Activated Plant Defense Responses through BRI1-EMS-SUPPRESSOR1 (BES1).Plant physiology · 2020Article
- Article
- Super-Multiple Deletion Analysis of Type III Effectors inFrontiers in microbiology · 2020Article
- Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System.Frontiers in genetics · 2020Review
- Comprehensive Identification of PTI Suppressors in Type III Effector Repertoire Reveals thatInternational journal of molecular sciences · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Ralstonia solanacearum, one of the most destructive plant bacterial pathogens, delivers an array of effector proteins via its type III secretion system for pathogenesis. However, the biochemical functions of most of these proteins remain unclear. RipN is a type III effector with unknown function(s) from the pathogen R. solanacearum. Here, we demonstrate that RipN is a conserved type III effector found within the R. solanacearum species complex that contains a putative Nudix hydrolase domain and has ADP-ribose/NADH pyrophosphorylase activity in vitro. Further analysis shows that RipN localizes to the endoplasmic reticulum (ER) and nucleus in Nicotiana tabacum leaf cells and Arabidopsis protoplasts, and truncation of the C-terminus of RipN results in a loss of nuclear and ER targeting. Furthermore, the expression of RipN in Arabidopsis suppresses callose deposition and the transcription of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) marker genes under flg22 treatment, and promotes bacterial growth in planta. In addition, the expression of RipN in plant cells alters NADH/NAD
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