ArticleJournal of veterinary internal medicine2019
Hepatic leptospiral infections in dogs without obvious renal involvement.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Clinical and sero-diagnosis of feline leptosprosis in the sleman region of Yogyakarta, Indonesia.Open veterinary journal · 2026Article
- A Scoping Review of Antimicrobial Therapy inAnimals : an open access journal from MDPI · 2025Review
- A Case of Canine Hepatitis with Hepatocellular Attack by Non-Neoplastic Perforin-Laden Lymphocytes.Veterinary sciences · 2025Article
- Computed Tomographic Findings in Dogs with Hepatic Bacterial Parenchymal Infection and Abscessation.Animals : an open access journal from MDPI · 2024Article
- Adjunctive intravesical EDTA-tromethamine treatment of a biofilm-associated recurrentThe Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Fluorescent In Situ Hybridization for the Detection of Intracellular Bacteria in Companion Animals.Veterinary sciences · 2024Review
- Seroepidemiological Analysis of Canine Leptospira Species Infections in Changchun, China.Pathogens (Basel, Switzerland) · 2023Article
- Atypical Lesions in Canine Leishmaniosis: Description of New Cases.Animals : an open access journal from MDPI · 2022Article
- Isolation ofPathogens (Basel, Switzerland) · 2022Article
- Seroepidemiological Analysis of Leptospiral infection using MAT in Stray Dogs in Alborz, Iran.Archives of Razi Institute · 2021Article
- Unusual case of pyogranulomatous hepatitis of suspected infectious etiology in a 3-year-old Labrador retriever dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs.Journal of veterinary internal medicine · 2019Article
- Hepatic leptospiral infections in dogs without obvious renal involvement.Journal of veterinary internal medicine · 2019Article
- Leptospirosis and immune-mediated hemolytic anemia: A lethal association.Veterinary research forum : an international quarterly journal · 2019Article
- Outpatient Clinical Trial in Dogs With Leptospirosis Treated With Enrofloxacin Hydrochloride-Dihydrate (ENRO-C).Frontiers in veterinary science · 2019Article
- Characterization of clinical presentation, histological features, ultrasonographic findings, and survival in 29 dogs with granulomatous hepatitis.Journal of veterinary internal medicineArticle
- Updated ACVIM consensus statement on leptospirosis in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReports of chronic hepatitis in dogs caused by Leptospira spp. are confined to small case series. Fluorescence in situ hybridization (FISH) allows the identification of spirochetes in liver samples. Consequently, this technique may help elucidate the role of Leptospira spp. in cases of chronic hepatitis.
objectivesTo describe cases of hepatic leptospirosis in dogs diagnosed by FISH and subsequent polymerase chain reaction (PCR) speciation, with the absence of clinically relevant renal involvement. ANIMALS: Ten client-owned dogs.
methodsRetrospective case series from the University of Cambridge presented between 2013 and 2016 or cases consulted by telephone advice during this time period. Cases were selected based on histopathologically confirmed granulomatous hepatitis and leptospiral organisms identified by FISH and PCR speciation (Leptospira interrogans/kirschneri).
resultsAll cases had increased liver enzyme activities, and FISH in combination with PCR speciation-confirmed infection with L. interrogans/kirschneri. Four dogs underwent repeat liver biopsy, FISH and PCR speciation 4-15 months after initial presentation and doxycycline treatment with 1 dog undergoing repeat sampling at necropsy. Three dogs that underwent repeat biopsy remained positive for L. interrogans/kirschneri infection. Six dogs were alive at the time of manuscript preparation and 4 dogs were euthanized as a result of progressive liver disease. CONCLUSIONS AND CLINICAL IMPORTANCE: The presence of hepatic leptospiral organisms may be associated with chronic granulomatous hepatitis without clinical evidence of renal involvement. Further studies are necessary to elucidate the etiological role of these organisms in the disease.
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