ArticleChembiochem : a European journal of chemical biology2019
Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.
Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Galectin-3 Mediates Endotoxin Internalization and Caspase-4/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury.Inflammation · 2024Article
- Exploring multivalent carbohydrate-protein interactions by NMR.Chemical Society reviews · 2023Review
- Agglutination of Human Polyomaviruses by Using a Tetravalent Glycocluster as a Cross-Linker.ACS omega · 2020Article
- Glucose and Maltose Surface-Functionalized Thermoresponsive Poly(Biomacromolecules · 2020Article
- Targeting Galectins With Glycomimetics.Frontiers in chemistry · 2020Review
- Review
- Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity.Organic chemistry frontiers : an international journal of organic chemistry · 2019Article
- Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates.Molecules (Basel, Switzerland) · 2019Article
- Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.Chembiochem : a European journal of chemical biology · 2019Article
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Authors and funding
7 authors.
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Abstract
The quest for novel natural-like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates by proteins modulates a number of important biological processes. These molecular recognition events are, however, difficult to study by the use of naturally occurring oligosaccharides and polysaccharides owing to their intrinsic structural heterogeneity and to the many technical difficulties encountered during the isolation of sufficient quantities of pure material for detailed structural and biological studies. Therefore, the construction of homogenous biomolecular probes that can mimic both the biophysical properties of polysaccharide backbones and the properties of bioactive oligosaccharide fragments are highly sought after. Herein, synthetic methodology for the construction of well-defined bioconjugates consisting of biologically relevant disaccharide fragments grafted onto a dextran backbone is presented, and a preliminary NMR spectroscopy study of their interactions with galectin-3 as a model lectin is conducted.
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