Evidence map›Paper›PMID 30499076›Full record

ArticlePathology oncology research : POR2019

Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism.

Maria João Carvalho, Mafalda Laranjo, Ana Margarida Abrantes, João Casalta-Lopes, Daniela Sarmento-Santos, Tânia Costa, Beatriz Serambeque, Nuno Almeida, Telmo Gonçalves, Catarina Mamede and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pathology oncology research : POR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Ring-fused chlorin-enhanced photodynamic therapy for effective cell death induction in endometrial cancer.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Applications of Photodynamic Therapy in Endometrial Diseases.Bioengineering (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Endometrial Cancer Stem Cells: Where Do We Stand and Where Should We Go?International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria João CarvalhoGynecology Service, Coimbra Hospital and Universitary Centre, Coimbra, Portugal. mariajoaosflcarvalho@gmail.com.ORCID http://orcid.org/0000-0001-9409-5466
Mafalda LaranjoBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Ana Margarida AbrantesBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
João Casalta-LopesBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Daniela Sarmento-SantosBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Tânia CostaBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Beatriz SerambequeBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Nuno AlmeidaBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Telmo GonçalvesBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Catarina MamedeBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
João EncarnaçãoBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Rui OliveiraPathology Service, Coimbra Hospital and Universitary Centre, Coimbra, Portugal.
Artur PaivaFlow Cytometry Unit, Coimbra Hospital and Universitary Centre, Coimbra, Portugal.
Rui de CarvalhoCentre for Functional Ecology, Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal.
Filomena BotelhoBiophysics Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Carlos OliveiraInstitute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Funding

Fundação para a Ciência e a Tecnologia SFRH/SINTD/60068/2009Universidade de Coimbra CIMAGO
6 · The paper itself

Abstract

This study aimed to characterize endometrial cancer regarding cancer stem cells (CSC) markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism. Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. The first spheres generation (ES1) was cultured in adherent conditions (G1). This procedure was repeated and was obtained generations of spheres (ES1, ES2 and ES3) and spheres-derived cells in adherent conditions (G1, G2 and G3). Populations were characterized regarding CD133, CD24, CD44, aldehyde dehydrogenase (ALDH), hormonal receptors, HER2, P53 and β-catenin, fluorine-18 fluorodeoxyglucose ([

Indexed as

Oxidative StressAC133 AntigenAnimalsApoptosisbeta CateninBiomarkers, TumorCell ProliferationEndometrial NeoplasmsFemaleGlucoseHumansHyaluronan ReceptorsMiceMice, Inbred BALB CMice, NudeNeoplastic Stem CellsAC133 Antigenbeta CateninBiomarkers, TumorCD44 protein, humanCTNNB1 protein, humanGlucoseHyaluronan ReceptorsEndometrial neoplasmsGlucose metabolismNeoplastic stem cells

Identifiers

PMID30499076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.