ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
The role of depression in the relationship between cognitive decline and quality of life among breast cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health-related quality of life in Her2-positive early breast cancer woman using trastuzumab: A systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Trial
- Symptom Structure, Heterogeneity, and Network Features on Postoperative Day 3 After Oesophagectomy: A Multisite, Cross-sectional, Multimethod Analysis.Annals of surgical oncology · 2026Article
- Construction and validation of a risk-prediction model for chemotherapy-related cognitive impairment in patients with breast cancer.Journal of cancer survivorship : research and practice · 2025Observational
- Chronic stress enhances glycolysis and promotes tumorigenesis.Frontiers in oncology · 2025Article
- The challenge of chemotherapy-related cognitive impairment: assessing and managing cognitive decline after cancer treatment.Ecancermedicalscience · 2025Review
- Association between cognitive functioning and health-related quality of life and its mediation by depressive symptoms in older patients with kidney failure.Journal of nephrology · 2024Observational
- A Structural Equation Model for Understanding the Relationship between Cognitive Reserve, Autonomy, Depression and Quality of Life in Aging.International journal of environmental research and public health · 2024Article
- Article
- Cognitive appraisal and depression in cancer patients undergoing chemotherapy: mediation by perceived stress and self-efficacy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Cognitive functioning in women with breast cancer: psychometric properties of the Arabic version of the Functional Assessment of Cancer Therapy-Cognitive Function Tool.Health and quality of life outcomes · 2023Article
- Clinical and genetic factors associated with self-reported cognitive deficits in women with breast cancer: the "CAGE-Cog" study.BMC cancer · 2022Article
- Fatigue among post-hematopoietic stem cell transplant patients in Jordan: prevalence and associated factors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- The Influence of Rehabilitation on Quality of Life in Breast Cancer Survivors: A Clinical Study.International journal of environmental research and public health · 2021Article
- The effect of fear of progression on quality of life among breast cancer patients: the mediating role of social support.Health and quality of life outcomes · 2021Article
- Chemotherapy-related subjective cognitive impairment in breast cancer patients in semi-rural South Africa.Health SA = SA Gesondheid · 2021Article
- The Impact of AC and AC-T Chemotherapy's Toxicities on Quality of Life Among Women with Breast Cancer in Ethiopia: A Prospective Patient-Reported Outcomes Study.Breast cancer (Dove Medical Press) · 2021Article
- Article
- Cognitive and Psychological Impacts of Different Treatment Options for Prostate Cancer: A Critical Analysis.Current urology · 2020Review
- Changes in Attentional Function in Patients From Before Through 12 Months After Breast Cancer Surgery.Journal of pain and symptom management · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCancer patients who underwent chemotherapy experience cognitive decline, which, in turn, negatively impacts quality of life (QoL). Depression is considered a psychological factor that is negatively associated with the QoL of cancer patients. However, the relationships among cognitive functioning, depression, and QoL in breast cancer patients are under-researched in the literature. The aim of this cross-sectional study was to identify the role of depression in the relationship between cognitive functioning and QoL among breast cancer patients.
methodsOne hundred thirty breast cancer patients who underwent primary treatment participated. Participants completed the Functional Assessment of Cancer Therapy-Cognitive Function version 3, the Montreal Cognitive Assessment, the Beck Depression Inventory-II, and the Functional Assessment of Cancer Therapy-Breast Scale. The data were analyzed using multiple regression according to Baron and Kenny's strategies and the Sobel test.
resultsSubjective and objective cognitive functioning and depression were statistically significant predictors of QoL in breast cancer patients. Depression played a partial mediating role in the relationship between objective cognitive functioning and QoL and between subjective cognitive functioning and QoL. Additionally, the Sobel test demonstrated that depression had a significant partial mediating effect between subjective cognitive functioning and QoL (Z = 4.91, p < 0.001) and between objective cognitive functioning and QoL (Z = 2.62, p = 0.009).
conclusionsThe findings indicated that depression could influence the association between cognitive functioning and QoL in breast cancer patients. Healthcare providers should develop an intervention focused on decreasing depression to evaluate the effectiveness of improving quality of life for breast cancer patients with cognitive dysfunction.
Indexed as
Identifiers
30498990What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.