Evidence map›Paper›PMID 30498973›Full record

ArticleEJNMMI physics2018

Impact of

Justin K Mikell, Ravi K Kaza, Peter L Roberson, Kelly C Younge, Ravi N Srinivasa, Bill S Majdalany, Kyle C Cuneo, Dawn Owen, Theresa Devasia, Matthew J Schipper and 1 more

Abstract read
In one paragraph

Article in EJNMMI physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin K MikellDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA. jusmikel@med.umich.edu.ORCID http://orcid.org/0000-0003-0679-7199
Ravi K KazaDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Peter L RobersonDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Kelly C YoungeDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Ravi N SrinivasaDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Bill S MajdalanyDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kyle C CuneoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Dawn OwenDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Theresa DevasiaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Matthew J SchipperDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
Yuni K DewarajaDepartment of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.

Funding

Imaging and Dosimetry of Yttrium-90 for Personalized Cancer TreatmentR01EB022075 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DEWARAJA, YUNI K · 2016 to 2023
$4.7M
National Institute of Biomedical Imaging and Bioengineering R01 EB022075NIBIB NIH HHS R01 EB022075
6 · The paper itself

Abstract

backgroundThe purpose was to validate

resultsIn phantoms, PS demonstrated high accuracy in lesion volumes (within 15%), AD metrics (within 11%), high spatial concordance relative to morphologic segmentation (DSC > 0.86 and MDA < 1.5 mm), and low intra-observer variability (DSC > 0.99, MDA < 0.2 mm, AD/BED metrics within 2%). For patients (58 lesions), spatial concordance between PS and MS was degraded compared to in-phantom (average DSC = 0.54, average MDA = 4.8 mm); the average mean tumor AD was 226 ± 153 and 197 ± 138 Gy, respectively for PS and MS. For patient AD metrics, the best Pearson correlation (r) and concordance correlation coefficient (ccc) between segmentation methods was found for mean AD (r = 0.94, ccc = 0.92), but worsened as the metric approached the minimum dose (for D90, r = 0.77, ccc = 0.69); BED metrics exhibited a similar trend. Patient PS showed low intra-observer variability (average DSC = 0.81, average MDA = 2.2 mm, average AD/BED metrics within 3.0%).

conclusions

Indexed as

90Y90Y PETAuto-segmentationDosimetryGradient-based segmentationRadioembolizationTumor segmentation

Identifiers

PMID30498973
PMCPMC6265358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.