ArticleArchives of gynecology and obstetrics2019
Incidence and groups at risk for unexpected uterine leiomyosarcoma: a Dutch nationwide cohort study.
Article in Archives of gynecology and obstetrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
- Prognostic Significance of the Ki-67 Index with an Optimal Cut-off Value of 32.5% in Uterine Sarcoma and Uterine Carcinosarcoma: A Retrospective Cohort Study.International journal of women's health · 2026Article
- MicroRNAs in Uterine Leiomyosarcoma: From Molecular Mechanisms to Clinical Applications.International journal of molecular sciences · 2025Review
- Accuracy of Frozen Section and Clinical/Radiological Diagnosis with Final Histopathology of Pelvic Masses in a Teaching Institute with a Non-oncology Setup, in Northeast India.Journal of obstetrics and gynaecology of India · 2023Article
- Prognostic factors and survival of patients with uterine sarcoma: a German unicenter analysis.Archives of gynecology and obstetrics · 2023Article
- Clinical manifestations and prognosis of unexpected uterine sarcoma of uterine fibroids in Tianjin China.BMC women's health · 2022Article
- Development of a deep learning method for improving diagnostic accuracy for uterine sarcoma cases.Scientific reports · 2022Article
- Clinical characteristics and prognosis analysis of uterine sarcoma: a single-institution retrospective study.BMC cancer · 2022Review
- Retrospective Analysis of Patients with Gynaecological Uterine Sarcomas in a Tertiary Hospital.Journal of personalized medicine · 2022Article
- Prevalence and occult rates of uterine leiomyosarcoma.Medicine · 2020Observational
- Rethinking the Issue of Power Morcellation of Uterine Fibroids: Is Morcellation the Real Problem or Is this Another Symptom of Disparity in Healthcare Provision?In vivo (Athens, Greece)Review
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the risk of uterine leiomyosarcoma in patients undergoing gynecological surgery and also to identify groups at risk for unrecognized uterine leiomyosarcoma.
methodsA national cohort study was performed evaluating all uterine leiomyosarcoma (ULMS) diagnosed in The Netherlands between January 2000 and September 2015. Cases were identified and supplied by the nationwide network and registry of histo- and cytopathology in The Netherlands (PALGA). Unexpected and expected ULMS were compared. Approval for this study was granted by the Medical Ethics Committee of all participating hospitals and by the review board of PALGA.
results262 original cases were included. The overall incidence of ULMS in our study was 0.25% or 1:400 patients. The incidence of unexpected ULMS was 0.12% or 1:865 patients. Preoperatively, a malignancy was unexpected in 46% of the cases and expected in 54%. Abnormal uterine bleeding constituted most of the symptoms. 90% of women underwent abdominal hysterectomy and/or bilateral salpingo-oophorectomy.
conclusionsLeiomyosarcoma are rare. Women aged 40-50 years with abnormal uterine bleeding are most at risk for unexpected ULMS. In contrast, this risk is low in postmenopausal women. ULMS were highly uncommon in women aged under 40 years.
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