Evidence map›Paper›PMID 30498959›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2019

A new ovine model of spine and chest wall deformity at birth with alteration of respiratory system mechanics and lung development: a feasibility study.

Stefan Parent, Nathalie Samson, Jesse Shen, Gabriel Gutman, Sarah Bouchard, Bruno Piedboeuf, Jean-Paul Praud

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stefan ParentDepartment of Surgery, Centre de recherche du CHU Sainte-Justine, 3175 Côte-Sainte Catherine, Montreal, H3T 1C5, QC, Canada. stefan.parent@umontreal.ca.ORCID 0000-0002-4854-2816
Nathalie SamsonNeonatal Respiratory Research Unit, Departments of Pediatrics and Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada.
Jesse ShenDepartment of Surgery, Centre de recherche du CHU Sainte-Justine, 3175 Côte-Sainte Catherine, Montreal, H3T 1C5, QC, Canada.
Gabriel GutmanDepartment of Surgery, Centre de recherche du CHU Sainte-Justine, 3175 Côte-Sainte Catherine, Montreal, H3T 1C5, QC, Canada.
Sarah BouchardDepartment of Surgery, Centre de recherche du CHU Sainte-Justine, 3175 Côte-Sainte Catherine, Montreal, H3T 1C5, QC, Canada.
Bruno PiedboeufDepartment of Pediatrics, Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada.
Jean-Paul PraudNeonatal Respiratory Research Unit, Departments of Pediatrics and Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CAUniversité de Sherbrooke · CACentre hospitalier universitaire de Québec · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop an animal model of spine and chest wall deformity (CWD) at birth and to evaluate its effects on respiratory system mechanics and lung development.

methodsA spine and CWD was created in utero between 70 and 75 days of gestation in six ovine fetuses by resection of the seventh and eighth left ribs. Two days after birth, respiratory system mechanics was assessed in anesthetized lambs using the flexiVent apparatus, followed by postmortem measurement of lung mechanics as well as histological lung analysis.

resultsA range of severity of CWD was found (Cobb angle from 0° to 48°) with a mean decrease in compliance of 47% and in inspiratory capacity of 39% compared to control lambs. Proof-of-concept histological analysis in one lamb showed marked lung hypoplasia.

conclusionOur ovine model represents a pilot proof-of-concept study evaluating the impact of a spine and CWD present at birth on lung respiratory mechanics and development. This study lays down the groundwork for future studies evaluating the impact of these deformities on lung development and potential treatments. These slides can be retrieved under Electronic Supplementary Material.

Indexed as

Disease Models, AnimalSpineThoracic WallAnimalsFemaleFetusMusculoskeletal AbnormalitiesPregnancyRange of Motion, ArticularRespiratory MechanicsSheepAnimal modelChest wall deformityFetal surgeryLambRespiratory function

Identifiers

PMID30498959
OpenAlexW2902943979

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.