Evidence map›Paper›PMID 30498945›Full record

ArticleInvestigational new drugs2019

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines.

Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, Walter Granig, Marek Murias, Thomas Erker

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigational new drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Malgorzata KucinskaDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland. kucinska@ump.edu.pl.
Helena MieszczakDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland.
Hanna Piotrowska-KempistyDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland.
Mariusz KaczmarekDepartment of Immunology, Poznan University of Medical Sciences, Poznan, Poland.
Walter GranigDepartment of Medicinal Chemistry, University of Vienna, Vienna, Austria.
Marek MuriasDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30 Street, 60-631, Poznan, Poland. marek.murias@ump.edu.pl.
Thomas ErkerDepartment of Medicinal Chemistry, University of Vienna, Vienna, Austria.
Poznan University of Medical Sciences · PLUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N'-(1,2-phenylene)bis3,4,5-trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound in an experimental model employing A549 lung adenocarcinoma cells and CCD39Lu non-tumorigenic lung fibroblasts. Since the results suggested oxidative stress as a co-existing mechanism of the cytotoxic effect exerted by 63 T on tested cells, studies involving the analysis of reactive oxygen species (ROS) generation and markers of oxidative stress in cells incubated with 63 T were carried out. It may be concluded that the selective activity of 63 T against cancer cells shown in our experiments is caused, at least in part, by the response of the tested cells to 63 T mediated oxidative stress in both tested cell lines.

Indexed as

Adenocarcinoma of LungAntineoplastic AgentsApoptosisBenzene DerivativesCell ProliferationCells, CulturedDNA DamageFibroblastsHumansLipid PeroxidationLungLung NeoplasmsOxidative StressReactive Oxygen SpeciesThioamidesAntineoplastic AgentsBenzene DerivativesN,N'-(1,2-phenylene)bis(3,4,5-trifluorobenzothioamide)Reactive Oxygen SpeciesThioamidesAntioxidative enzymesLung cancerLung fibroblastOxidative stressReactive oxygen species

Identifiers

PMID30498945
PMCPMC6736908
OpenAlexW2902757753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.