ArticleCancer causes & control : CCC2019
Pre- and perinatal factors and incidence of breast cancer in the Black Women's Health Study.
Article in Cancer causes & control : CCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Association of birth weight with cancer risk: a dose-response meta-analysis and Mendelian randomization study.Journal of cancer research and clinical oncology · 2023Pooled it
- The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.PloS one · 2020Pooled it
- Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.Communications medicine · 2026Article
- Global evolution of breast cancer incidence in childbearing-age women aged 15-49 years: a 30-year analysis.Journal of cancer research and clinical oncology · 2025Article
- Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk.JAMA network open · 2024Article
- Investigating the Relationship between Birthweight and Breast Cancer from A Non-Linear and Mediation Perspective.Iranian journal of public health · 2024Article
- Circadian Disruption Impacts Fetal Development in Mice Using High-Frequency Ultrasound.Journal of circadian rhythms · 2024Article
- Prenatal exposure to maternal smoking and adult lung cancer risk: a nested case-control study using peripheral blood leukocyte DNA methylation prediction of exposure.Environmental epigenetics · 2024Article
- Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation.Nature communications · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality.Journal of translational medicine · 2022Article
- Perinatal factors, female breast cancer, and associated risk factors in Puerto Rico: evidence from the Atabey epidemiology of breast cancer study.Cancer causes & control : CCC · 2022Article
- Cancer Progress and Priorities: Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of the study was to investigate the association between pre- or perinatal factors and breast cancer risk among African American women.
methodsParticipants in the Black Women's Health Study, a prospective cohort of 59,000 African American women, reported birth weight, preterm birth, twin or triplet status, maternal age at birth, birth order, and having been breastfed during infancy at various times during follow-up from 1997 to 2015. Numbers of incident cases ranged from 312 for breastfed analyses to 1,583 for twin or triplet analyses. Using multivariable Cox proportional hazards regression, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between each factor and breast cancer risk overall and by estrogen receptor (ER) status.
resultsCompared to birth weights of 5 lbs. 8 oz.-8 lbs. 13 oz., low (< 5 lbs. 8 oz.) and high (> 8 lbs. 13 oz.) birth weights were associated with increased breast cancer risk; HRs (95% CI) were 1.19 (0.98-1.44) and 1.26 (0.97-1.63), respectively. Associations were similar by ER status. Having been born to a mother aged ≥ 35 years versus < 20 years was associated with risk of ER+ (HR 1.59, 95% CI 1.10-2.29), but not ER- breast cancer. Other perinatal factors were not associated with breast cancer.
conclusionAfrican American women with a low or high birth weight or born to older mothers may have increased breast cancer risk. Trends towards delayed child birth and higher birth weights, coupled with disproportionately high rates of low birth weight among African Americans, may contribute to increases in breast cancer incidence.
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