Trial reportThe journal of nutrition, health & aging2018
Quality of Life and Mental Health in Older Adults with Obesity and Frailty: Associations with a Weight Loss Intervention.
Trial report in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Nutritional interventions and sleep quality in obese individuals: a systematic review and meta-analysis of randomized control trials.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Association of body mass index with disability in activities of daily living in older adults: a systematic review of the literature based on longitudinal data.BMC public health · 2025Pooled it
- [Prevalence, structure, and risk factors for mental disorders in older adults.]Advances in gerontology = Uspekhi gerontologii · 2021Pooled it
- Health-related quality of life among people with HIV at low-to-moderate risk for atherosclerotic cardiovascular disease in the REPRIEVE Trial.AIDS (London, England) · 2026Trial
- Effectiveness of combining Qingyanyin formulated granules with press needles in treating abdominal obesity: a multicenter randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study.Stem cell research & therapy · 2024Trial
- Impact of Moderate-Intensity Multicomponent Training on Cardiometabolic Health-Related Outcomes in Older Adults With Overweight and Obesity: A 9-Month Quasi-Experimental Single-Arm Pretest-Posttest Study.Australasian journal on ageing · 2026Article
- Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders.Journal of advanced research · 2026Article
- Mental health changes after 4 months of weight loss treatment with the glucagon-like peptide-1 analogue liraglutide 3.0 mg.Diabetes, obesity & metabolism · 2026Observational
- Does obesity affect outcomes or complications in the treatment of lumbar disc herniation after open lumbar microdiscectomy? A systematic review and meta-analysis.Brain & spine · 2026Review
- From fragmentation to integration: can social prescribing bridge the gap between multimorbidity and mental health in an ageing population?BMJ public health · 2026Review
- Physical Performance and Mental Health in Institutionalized Older Adults: A Multicenter, Cross-Sectional Observational Study.Healthcare (Basel, Switzerland) · 2025Article
- Occurrence of sleep disorders and the value of body mass index of seniors and the quality of their aging.Geriatrics & gerontology international · 2025Article
- Association between body mass index and happiness among young adults in Taiwan: a cross-sectional study.Frontiers in public health · 2025Article
- Cardiometabolic multimorbidity and frailty in middle-aged and older adults: a cross-nationally harmonized study.Frontiers in public health · 2025Article
- Association between Life's Essential 8 and frailty among the United States older people.Frontiers in public health · 2025Article
- Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE).Frontiers in aging neuroscience · 2025Article
- A study on the mental health and body weight of Chinese college students in the context of COVID-19: implications for educational practice.Frontiers in public health · 2025Article
- Correlation of ageing with Health related-quality of life of patients in 13 groups of disease in Poland.Scientific reports · 2024Article
- 3D built virtual arctic environment increase vigor through connectedness in older people.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the bi-directional associations of a weight loss intervention with quality of life and mental health in obese older adults with functional limitations.
designCombined-group analyses of secondary variables from the MEASUR-UP randomized controlled trial.
settingAcademic medical center.
participantsObese community-dwelling men and women (N = 67; age ≥60; BMI ≥30) with functional limitations (Short Physical Performance Battery [SPPB] score of 4-10 out of 12).
interventionSix-month reduced calorie diet at two protein levels. MEASUREMENTS: Weight, height, body composition, physical function, medical history, and mental health and quality of life assessments (Center for Epidemiologic Studies Depression Scale [CES-D]; Profile of Mood States [POMS], Pittsburgh Sleep Quality Index [PSQI]; Perceived Stress Scale [PSS]; Satisfaction with Life Scale [SWLS]; and Short Form Health Survey [SF-36]) were acquired at 0, 3 and 6 months.
resultsPhysical composite quality of life (SF-36) improved significantly at 3 months (β = 6.29, t2,48 = 2.60, p = 0.012) and 6 months (β = 10.03, t2,48 = 4.83, p < 0.001), as did several domains of physical quality of life. Baseline depression symptoms (CES-D and POMS) were found to predict lower amounts of weight loss; higher baseline sleep latency (PSQI) and anger (POMS) predicted less improvement in physical function (SPPB).
conclusionThe significant bi-directional associations found between a weight loss intervention and mental health/quality of life, including substantial improvements in physical quality of life with obesity treatment, indicate the importance of considering mental health and quality of life as part of any weight loss intervention for older adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.