ArticleThe journal of nutrition, health & aging2018
Nutritional and Frailty State Transitions in the Singapore Longitudinal Aging Study.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- How gait influences frailty models and health-related outcomes in clinical-based and population-based studies: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021Pooled it
- Malnutrition-induced frailty and risk of early rehospitalization in heart failure: A Survival analysis from a prospective cohort study.Pakistan journal of medical sciences · 2026Article
- Development and Validation of Machine Learning Models for Predicting Early Cognitive Decline Using Home Sensor-Derived Behavioral Data: Sensors in-Home for Elder Wellbeing (SINEW) Cohort Study.JMIR research protocols · 2026Article
- Predictors of progression from pre-frailty to frailty in older people: a systematic review and meta-analysis protocol.BMJ open · 2025Article
- Novel Resting Energy Expenditure Prediction Equations for Multi-Ethnic Asian Older Adults with Multimorbidity.Nutrients · 2025Article
- Inflammatory markers and clinical factors as key independent risk factors for frailty: a retrospective study.BMC geriatrics · 2025Article
- SCREEN-II: upstream identification of nutritional risks and its determinants among older adults in primary care in Singapore.BMJ nutrition, prevention & health · 2025Article
- Two-year longitudinal associations between nutritional status and frailty in community-dwelling older adults: Korean Frailty and Aging Cohort Study.BMC geriatrics · 2023Article
- Secondhand smoke is positively associated with pre-frailty and frailty in non-smoking older adults.Frontiers in psychiatry · 2022Article
- Frailty and risk of cardiovascular disease and mortality.PloS one · 2022Article
- Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study.Aging · 2021Article
- Nutritional Assessment in Older Adults : MNA® 25 years of a Screening Tool and a Reference Standard for Care and Research; What Next?The journal of nutrition, health & aging · 2021Article
- Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.The journal of nutrition, health & aging · 2020Observational
- Nutritional Risk and Mortality at One Year for Elderly Patients Hospitalized with Nonvalvular Atrial Fibrillation. Nonavasc Registry.The journal of nutrition, health & aging · 2020Article
- Frailty state among Indonesian elderly: prevalence, associated factors, and frailty state transition.BMC geriatrics · 2019Article
- Editorial: Aging Friendly Health Systems.The journal of nutrition, health & aging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition is a major determinant of the physical frailty syndrome. Dynamic transitions in frailty states over time is well documented, but few studies have documented temporal changes in nutritional states and whether they influence frailty outcomes.
designLongitudinal cohort study. SETTING AND
participantsCommunity-dwelling older Singaporeans aged ≥55y with a 5-year follow-up (n=1162) in the Singapore Longitudinal Ageing Study 2 (SLAS-2). MEASUREMENTS: The Mini Nutritional Assessment Short-Form (MNA-SF) was used to determine nutritional status, and the Fried's criteria (shrinking, weakness, slowness, exhaustion and inactivity) was used to assess physical frailty phenotype at both baseline and follow-up. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were adjusted for multiple baseline co-variables.
resultsAt baseline, being at risk of malnutrition/malnourished was associated with increased odds of prevalent pre-frailty (OR=2.76, 95% CI=1.86-4.10) and frailty (OR=4.10, 95% CI=1.41-11.9). Baseline robust individuals who were persistently at risk of malnutrition/malnourished showed an increased odds of conversion to being pre-frail/frail at follow-up (OR=3.45, 95% CI=1.00-11.9). Among baseline pre-frail/frail individuals, reversion to being robust were significantly less likely among those who were persistently at risk of malnutrition/malnourished (OR=0.26, 95% CI=0.10-0.67) and those whose baseline normal nutrition worsened at follow-up (OR=0.20, 95% CI=0.06-0.74).
conclusionChanges in nutritional states are associated with frailty state transitions, and monitoring changes in nutritional status is recommended for the prevention and severity reduction of frailty among older people in the community.
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