ArticleThe journal of nutrition, health & aging2018
Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Citrulline drives age-related lipid deposition for healthspan.Nature communications · 2026Article
- LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.Nature communications · 2025Article
- Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment.Frontiers in neuroscience · 2025Article
- Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.Aging cell · 2023Article
- Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study.Archives of gynecology and obstetrics · 2022Article
- Article
- Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours.Metabolites · 2022Review
- Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification.Frontiers in aging · 2021Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging is an acknowledged risk factor for most chronic diseases and functional impairments. The practicability of potential biomarkers of aging remains unsure. Moreover, biomarkers related to certain geriatric diseases, such as carotid atherosclerosis and multiple co-morbidities are less understood. The purpose of this study was to investigate the definite relationship between metabolic biomarkers and aging-related diseases.
methodsEighty-five male adults aged fifty years or older from the general population were enrolled. Plasma metabolic biomarkers, including fourteen amino acids and thirty-six acylcarnitines, were measured by liquid chromatography mass spectrometry. Bivariate correlation analysis was employed to estimate the correlations between variables and age, and also to evaluate the relationship between metabolic biomarkers and aging-related diseases. Receiver operating characteristic (ROC) curve was conducted to judge the diagnostic efficiency of potential metabolic biomarkers for co-morbidities.
resultsCertain metabolic biomarkers were strongly positively correlated with age, such as tetradecenoylcarnitine (C14:1), microalbumin-urine creatinine ratio (UACR), dodecenoylcarnitine (C12:1) and citrulline (p < 0.001). Carotid atherosclerosis and co-morbidities were positively correlated with aging (p < 0.001). After adjustment for age, hydroxytetradecanoylcarnitine (C14OH) remained positively correlated with carotid plague area. Besides, citrulline had diagnostic power for co-morbidities.
conclusionsCitrulline may be a promising metabolic biomarker in the middle-aged and elderly men. Larger-scale and long-term studies are needed to confirm our findings.
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